Paper Chromatography Amino Acids

Landua, Alton J.; Fuerst, Robert; Awapara, Jörge

doi:10.1021/ac60049a033

Cited by 32 publications

(7 citation statements)

References 11 publications

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“…Illhere polyfunctional basic compounds are chromatographed in acidic solvent systems, the explanation inost frequently invokecl is the generation of more than one ionic species of the base by reaction of the substance wit11 the mobile phase (20,21), but the formation of tautomers has also been postulated (22). Since clain poison has two basic centers and ldold et al (1) obtained some evidence from countercurrent distribution studies a t pH S that clam poisoil consists of two tautomers of diileri~ig toxicity, either of the explanations mentioned above was a possibility.…”

Section: Introductionmentioning

confidence: 99%

Clam Poison:i. The Paper Chromatographic Purification of Clam Poison Dihydrochloride

Casselman¹,

Greenhalgh²,

Brownell³

et al. 1960

Can. J. Chem.

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A semimicro (10–25 mg) paper chromatographic method for purification of clam poison has been developed. This procedure when applied to a partially purified (toxicity 4150 MU/mg) sample of the toxin gave a 74% recovery of clam poison dihydrochloride of purity identical with that of the best material obtained by Schantz etal. (2) via the alumina chromatographic method. The upper limit of purity of toxin resulting from paper chromatography is estimated to be 98% because of traces of impurity introduced by the paper. The paper chromatographic procedure has been found capable of enriching low-grade toxic residues (35%) from the alumina process to a purity of 75% with an over-all recovery of 70%.

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Section: Introductionmentioning

confidence: 99%

Clam Poison:i. The Paper Chromatographic Purification of Clam Poison Dihydrochloride

Casselman¹,

Greenhalgh²,

Brownell³

et al. 1960

Can. J. Chem.

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“…The results of the detailed examination of the effect of the pH of the sample are reported by Landua etal. on the paper chromatographic separation of these acids (121). By utilizing filter paper buffered to a selected pH, McFarren (128) has developed a one-dimensional separation scheme for 20 common amino acids.…”

Section: Proteins and Amino Acidsmentioning

confidence: 99%

Pharmaceuticals and Natural Drugs

Marsh¹,

Hilty²

1952

Anal. Chem.

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AS IS the case in all the major fields of the science, the litera-_ \_ ture pertaining to analytical chemistry is rapidly approaching a state of practical unwieldiness. One might say-and not too facetiously-that a detailed search of published information for an analytical project in applied analysis could conceivably involve a large proportion of the time devoted to the project itself. The number of annual published contributions to analytical studies of pharmaceutical and natural drugs alone is estimated to be nearly a thousand.The preparation of a review covering such a number and diversity of publications necessarily poses several problems. Foremost among these is the matter of selection of material, since it is obvious that an abstract of the contents of each article could not be included. The authors wish to repeat and to re-emphasize the fact that omissions from the review do not imply that the papers so omitted do not contain useful information. A conscious effort has been made, however, to include those studies and procedures which offer the greatest possibilities for use in pharmaceutical analysis.The classification of methods is the same as that published in the previous annual reviews of pharmaceuticals and natural drugs.

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“…A mino acid analyses by paper partition chromatography have often revealed the presence in biological materials of unknown ninhydrin-reacting substances. Subsequent identification of these unknown compounds has, in several instances, increased our knowledge of their natural occurrence (8).…”

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confidence: 99%