Paper spray ionization: Applications and perspectives

McBride, Ethan M.; Mach, Phillip M.; Dhummakupt, Elizabeth S.; Dowling, Sarah; Carmany, Daniel; Demond, Paul S.; Rizzo, Gabrielle M.; Manicke, Nicholas E.; Glaros, Trevor

doi:10.1016/j.trac.2019.06.028

Cited by 86 publications

(58 citation statements)

References 54 publications

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“…Compare to other methods in the same group, PSI has shown the greatest potential for quantitative analysis [9]. Since the invention of PSI by the Cooks group in 2010 [10], PSI has been applied widely in several fields of analytical chemistry such as clinical, food, forensic, environmental, mechanistic, and reaction monitoring studies [11].…”

Section: Figure 1 Classification Of Desorption Methods In Ai-msmentioning

confidence: 99%

Ứng dụng khối phổ ion hóa sử dụng giấy và ion hóa trực tiếp chất nền trong kiểm soát thực phẩm+

Kim¹,

Gwangju²

2020

VJFC

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Trong phân tích thực phẩm, khối phổ là kỹ thuật được sử dụng ngày càng rộng rãi. Những năm gần đây thế giới chứng kiến sự ra đời của nhiều loại nguồn ion hóa mới ghép nối với khối phổ, chúng đã thay đổi cách mà các nhà khoa học phân tích thực phẩm. Nguồn ion hóa sử dụng vật liêu giấy để ion hóa mẫu và các biến thể tương tự khác của nó là những ví dụng thành công của nhóm các nguồn ion hóa mới này. Trong bài tổng quan này, những ứng dụng của nguồn ion hóa sử dụng giấy và các biến thể của nó trong việc kiểm soát thực phẩm với những mục đích khác nhau đã được trình bày. Những hạn chế vốn có và phương pháp khắc phục của kỹ thuật này cũng được bàn luận trong bài viết này. Ở phần cuối cùng, chúng tôi sẽ đưa ra những ý kiến về tiềm năng phát triển của các nguồn ion hóa mới này trong tương lai. +Ghi chú/Note: Tiêu đề và tóm tắt tiếng Việt do Ban Biên tập biên dịch với sự đồng ý của tác giả/The Vietnamese title and abstract is translated by the Editorial Board with the agreement of the Author.

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Section: Figure 1 Classification Of Desorption Methods In Ai-msmentioning

confidence: 99%

Ứng dụng khối phổ ion hóa sử dụng giấy và ion hóa trực tiếp chất nền trong kiểm soát thực phẩm+

Kim¹,

Gwangju²

2020

VJFC

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“…Paper spray ionization (PSI) [95] is another form of ambient ionization, where ions of an analyte are formed by applying a high potential to a triangular paper dropped with a small volume (<10 μL) of solution. Samples are either preloaded on the paper or added via a spray solution [96] .…”

Section: Electrochemistry In Ms Ion Sourcesmentioning

confidence: 99%

Recent Advances of In‐Source Electrochemical Mass Spectrometry

et al. 2021

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Hyphenation of electrochemistry (EC) and mass spectrometry has become a powerful tool to study redox processes. Approaches that can achieve this hyphenation include integrating chromatography/electrophoresis between electroinduced redox reactions and detection of products, coupling an EC flow cell to a mass spectrometer, and performing electrochemical reactions inside the ion source of a mass spectrometer. The first two approaches have been well reviewed elsewhere. This Minireview highlights the inherent electrochemical properties of many mass spectrometry ion sources and their roles in the coupling of electrochemistry and mass spectrometric analysis. Development of modified ion sources that allow the compatibility of electrochemistry with ionization processes is also surveyed. Applications of different in-source electrochemical devices are provided including intermediate capturing, bioanalytical studies, nanoparticle formation, electrosynthesis, and electrode imaging.

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“…The method of PS‐MS, a direct, ambient ionization method that is relatively new, evolved from initial work by Cooks and Ouyang at Purdue University in 2010 . Its applications are broad and continually growing, extending to environmental, forensic, biological, and industrial areas, amongst others . In PS‐MS, laborious sample preparations are largely obviated, as raw sample is simply deposited directly onto a triangular piece of paper by swiping, micropipetting, etc.…”

Section: Overview Of Ps‐ms Techniquementioning

confidence: 99%

“…In addition to minimized matrix effects for complex samples over wide concentration ranges, PS‐MS routinely achieves picogram level detection limits . This level of sensitivity may initially seem unnecessary for drug checking, given that typical lethal human doses of fentanyl and related analogs occur at microgram to milligram levels .…”

Section: Sensitivity and Quantitative Capabilitiesmentioning

confidence: 99%

Paper spray mass spectrometry: A new drug checking tool for harm reduction in the opioid overdose crisis

Vandergrift

Gill

2019

J Mass Spectrom

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Fentanyl and related psychoactive substances are at the forefront of the opioid overdose crisis, for which a complete solution is not immediately obvious. Drug testing for harm reduction may be an effective approach to both reduce overdoses and importantly, engage people who use drugs (PWUD) with the medical system. Paper spray mass spectrometry (PS-MS) is an ambient ionization strategy that is uniquely suited to address this complicated analytical task. This perspectives article presents the merits of PS-MS, with a focus upon the current state of its use as a candidate drug checking strategy for harm reduction. PS-MS is inherently sensitive and selective, with detection limits in the picogram range. It requires small drug samples (~1 mg) for quantitative drug testing, critical to encourage pre-consumption measurements by PWUD in the context of a harm reduction strategy. Calibrations obtained in surrogate drug matrices containing highly concentrated primary drugs demonstrate comparable sensitivities, a wide calibration range, and minimal matrix effects. PS-MS can be interfaced with high-resolution MS for non-targeted analysis, allowing the identification of novel psychoactive substances as they appear in street drugs. Individual quantitative PS-MS measurements for drug testing can be done in 1 minute or less, resulting in high sample throughput. Significant advancement in mass spectrometer miniaturization and mobilization has concomitant benefits for direct, on-site drug checking, such as reduced cost, simplified maintenance and ease of use by less skilled operators. While PS-MS technology continues to rapidly advance, it is our opinion that PS-MS can be utilized as an effective tool for harm reduction in the opioid overdose crisis. KEYWORDS direct mass spectrometry, drug checking, harm reduction, opioid overdose crisis, paper spray mass spectrometry (PS-MS)

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Paper spray ionization: Applications and perspectives

Cited by 86 publications

References 54 publications

Ứng dụng khối phổ ion hóa sử dụng giấy và ion hóa trực tiếp chất nền trong kiểm soát thực phẩm+

Ứng dụng khối phổ ion hóa sử dụng giấy và ion hóa trực tiếp chất nền trong kiểm soát thực phẩm+

Recent Advances of In‐Source Electrochemical Mass Spectrometry

Paper spray mass spectrometry: A new drug checking tool for harm reduction in the opioid overdose crisis

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