2014
DOI: 10.4155/bio.13.310
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Paper Spray-MS for Bioanalysis

Abstract: This Review provides a general understanding of paper spray-MS, including the methodology and theory associated with a number of different related applications. This method has become a direct sampling/ionization method for mass spectrometric analysis at ambient conditions and, as a result, it has greatly simplified and increased the speed of mass-spectrum analysis. It has now become an increasingly popular and important method for MS. The first part of this review discusses the fundamentals of paper spray. So… Show more

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Cited by 57 publications
(50 citation statements)
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“…34 The direct aspiration of material onto paper for PS analysis eliminates smearing and may provide additional advantages in regards to MS analysis. FNA smear data applied to a tissue section-based classification system yielded an average prediction rate of 87.5% for disease states.…”
Section: Resultsmentioning
confidence: 99%
“…34 The direct aspiration of material onto paper for PS analysis eliminates smearing and may provide additional advantages in regards to MS analysis. FNA smear data applied to a tissue section-based classification system yielded an average prediction rate of 87.5% for disease states.…”
Section: Resultsmentioning
confidence: 99%
“…Paper spray has been used to detect and quantitate pharmaceuticals in blood and even for the direct analysis of biological tissues . However, the range of compounds that can be successfully analysed by this relatively new ionization technique has yet to be fully explored …”
Section: Introductionmentioning
confidence: 99%
“…2A) by loading a paper substrate with the mixture of analytes and spray solvent followed by applying with a high voltage. Paper spray has been applied in di erent elds such as bioanalysis, 48) pharmacokinetics, 49,50) forensics, 51) microbiology, 52,53) and food science. 54,55) Recently, the technique has been commercialized by Prosolia under the trade name PaperSpray.…”
Section: Paper Spraymentioning
confidence: 99%