Papillary carcinoma with extensive squamous metaplasia arising from thyroglossal duct cyst in an 11-year-old girl: significance of differentiation from squamous cell carcinoma: a case report

Gomi, Kiyoshi; Kitagawa, Norihiko; Usui, Yoshiko; Tanaka, Mio; Yoshida, Misao; Hirata, Yoshihiro; Kosaka, Taiichiro; Honda, Shohei; Take, Hiroshi; Sato, Masato; Shishikura, Ayako; Aida, Noriko; Ohhama, Youkatsu; Tanaka, Yukichi

doi:10.1016/j.jpedsurg.2010.10.030

Cited by 17 publications

(16 citation statements)

References 14 publications

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“…Papillary carcinoma (PTC) is the most common, as it is in the thyroid gland, ranging between 85.5%-94% [10, 17]. However, mixed papillary/follicular (4.4%), follicular thyroid (1.1%), squamous cell (6.6%), adenocarcinoma (2.2%), Hürthle cell, and anaplastic thyroid carcinomas can be diagnosed [16, 18, 30–33]. A case each of concurrent papillary thyroid with squamous cell carcinoma and adenosquamous carcinoma, have been reported in the literature [34, 35].…”

Section: Embryology and Pathophysiologymentioning

confidence: 99%

“…These malignancies can arise de novo in older adults, being reported in patients in their sixth and seventh decades of life (55 and 65 years old), or as squamous cell metaplasia of thyroid papillary histotype, in children under 15 years old [7, 8, 18]. The rare case reported of anaplastic thyroid carcinoma of the TGDR in an 84-year-old woman was associated with a benign follicular neoplasm [9].…”

Section: Embryology and Pathophysiologymentioning

confidence: 99%

“…Concomitant main thyroid gland malignancy has been reported to be present in 11–45% of cases [2, 3, 16, 18, 28, 29]. Synchronous papillary thyroid carcinomas in the TGDR and the thyroid gland are multifocal tumors, and hence this risk should be carefully evaluated.…”

Section: Managementmentioning

confidence: 99%

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Thyroglossal duct remnant carcinoma: Beyond the Sistrunk procedure

Carter¹,

Yeutter²,

Mazeh³

2014

Surgical Oncology

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Thyroglossal duct remnants (TGDRs) account for more than 70% of anterior neck masses in children and 7% in adults; however, cancer is identified in only 1–2% of the cases. The diagnosis of a TGDR is based on clinical manifestation of a painless, anterior neck swelling, which elevates with swallowing. Cytological evaluation with fine needle aspiration and biopsy (FNAB) may facilitate the pre-operative diagnosis of malignancy, as the majority of TGDR cancers are of papillary histotype. The recommended treatment for symptomatic TGDR without evidence of malignancy is a Sistrunk procedure, which entails en bloc resection of the remnant and the mid-portion of the hyoid bone. The optimal management of patients with diagnosed malignancy is controversial, and in the past, additional total thyroidectomy was recommended for all of these patients. The purpose of this study is to review the literature on TGDR carcinomas, present the evidence on the available diagnostic tools, identify the surgical and post-operative medical management strategies, discuss current controversies, and conclude with a management algorithm.

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Section: Embryology and Pathophysiologymentioning

confidence: 99%

Section: Embryology and Pathophysiologymentioning

confidence: 99%

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Thyroglossal duct remnant carcinoma: Beyond the Sistrunk procedure

Carter¹,

Yeutter²,

Mazeh³

2014

Surgical Oncology

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“…11 Papillary thyroid cancer was diagnosed in all reported patients younger than 20 years of age, and recently papillary carcinoma with extensive squamous cell metaplasia has been described in an 11-year-old girl. 12 Previous neck irradiation, a known predisposing factor for welldifferentiated thyroid cancer, has been very rarely described in patients with papillary carcinoma arising in TDCs. Medullary thyroid carcinoma has not been reported, as expected, as parafollicular cells have different embryological origin (from the ultimobranchial body) and migrate into the thyroid after its descent to its final position.…”

Section: Discussionmentioning

confidence: 99%

An Adolescent With a Rare Midline Neck Tumor

Vassilatou

Proikas

Margari

et al. 2014

Journal of Pediatric Hematology/Oncology

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Occurrence of malignancy in a thyroglossal duct cyst (TDC) in children and adolescents is very rare, preoperative diagnosis is a challenge, and appropriate management is still debated. We report a 19-year-old male patient referred for a midline neck mass diagnosed as an atypical TDC after initial and subsequent investigations. Ultrasound-guided fine-needle aspiration (FNA) of the mass was diagnostic for papillary thyroid carcinoma. Sistrunk procedure and total thyroidectomy were performed. Histologic analysis confirmed the presence of papillary thyroid carcinoma within TDC, infiltrating surrounding soft tissues. Postoperatively, radioiodine ablation treatment was administered, followed by TSH suppression therapy.

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“…While carcinoma of a thyroglossal duct cyst (TGDC) remains a rare finding, its incidence has been well characterized by case reports over the past three decades [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Current rates of carcinoma are estimated to be about 1% of all cysts [10].…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of a Thyroglossal Duct Cyst and the Role of a Level IA Neck Dissection

Henry

Mignone

Pepek³

et al. 2020

ORL

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Squamous cell carcinoma of a thyroglossal duct cyst is exceedingly rare, with less than 30 cases reported across the literature. Herein, we present a case of squamous cell carcinoma (SCC) of a thyroglossal duct cyst (TGDC) and discuss the utility of a level IA neck dissection in these cases. In 2018, a 62-year-old female presented to a university-affiliated otolaryngologist with symptoms of dysphagia and a palpable anterior midline neck mass. MRI demonstrated a 3.1 × 2.0-cm mass concerning an invasive TGDC. She was referred to our institution for further management. Preoperative imaging demonstrated an invasive TGDC but no pathological nodes. A Sistrunk procedure and a IA neck dissection were performed. Pathology demonstrated one pathological node in the neck dissection specimen. In summary, a bilateral IA neck dissection was performed on a clinically node zero (N0) patient, and a pathological node was ultimately identified. We hope that by introducing this idea of a IA neck dissection for SCC of a TGDC, we can prompt further investigation into the utility of this procedure for these uniquely rare cases.

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Papillary carcinoma with extensive squamous metaplasia arising from thyroglossal duct cyst in an 11-year-old girl: significance of differentiation from squamous cell carcinoma: a case report

Cited by 17 publications

References 14 publications

Thyroglossal duct remnant carcinoma: Beyond the Sistrunk procedure

Thyroglossal duct remnant carcinoma: Beyond the Sistrunk procedure

An Adolescent With a Rare Midline Neck Tumor

Squamous Cell Carcinoma of a Thyroglossal Duct Cyst and the Role of a Level IA Neck Dissection

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