Papillary glioneuronal tumor radiologically mimicking a cavernous hemangioma with hemorrhagic onset

Buccoliero, Anna Maria; Mussa, Federico; Taddei, Antonio; Genitori, Lorenzo; Taddei, Gian Luigi

doi:10.1111/j.1440-1789.2006.00674.x

Cited by 43 publications

(22 citation statements)

References 19 publications

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“…However, LC is an important endpoint, because recurrent gangliogliomas may have a malignant course, including craniospinal dissemination, or may cause neurologic symptoms (such as seizures) or intracerebral hemorrhage. 45,79,98,133,134,[147][148][149] In addition, locally recurrent tumors may require repeat craniotomies, which carry additional risks. Furthermore, anaplastic astrocytoma or even glioblastoma multiforme may develop at the time of recurrence.…”

Section: Discussionmentioning

confidence: 99%

The role of postoperative radiotherapy for the treatment of gangliogliomas

Rades

Zwick

Leppert

et al. 2009

Cancer

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BACKGROUND: Because of their rarity, no prospective studies have been performed regarding gangliogliomas. The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma. METHODS: In 402 patients with ganglioglioma, outcomes were compared for patients who underwent gross total resection alone (GTR) (n ¼ 188), GTR plus radiotherapy (GTR þ RT) (n ¼ 21), subtotal resection alone (STR) (n ¼ 113), and STR plus RT (STR þ RT (n ¼ 80). Age, sex, tumor site, and histologic grade also were investigated. Subgroup analyses were performed for both low-grade and high-grade tumors. RESULTS: The 10-year LC rates were 89% after GTR, 90% after GTR þ RT, 52% after STR, and 65% after STR þ RT (P < .001); and the 10-year OS rates were 95%, 95%, 62%, and 74%, respectively (P < .001). After STR, irradiation significantly improved LC (P ¼ .004) but not OS (P ¼ .22). After GTR, irradiation did not significantly improve LC (P ¼ .23) or OS (P ¼ .29). On multivariate analyses, LC and OS were associated with therapy and pathologic grade, and OS also was associated with tumor site. In low-grade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .18); and, after GTR, LC (P ¼ .28) and OS (P ¼ 1.0) were not improved with postoperative radiotherapy. In highgrade tumors, STR þ RT resulted in better LC (P ¼ .016) but not better OS (P ¼ .41); after GTR, LC (P ¼ .56) and OS (P ¼ .61) were not improved with irradiation. CONCLUSIONS: According to this review, GTR should be performed whenever safely possible and does not require postoperative irradiation. If only STR is achieved, then RT improves LC of both low-grade and high-grade tumors and, thus, should be considered seriously. Cancer 2010;116:432-42.

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Section: Discussionmentioning

confidence: 99%

The role of postoperative radiotherapy for the treatment of gangliogliomas

Rades

Zwick

Leppert

et al. 2009

Cancer

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“…[15] in young adults (mean age 27.2 1 18.36) with equal gender distribution. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Three case including our case were aged less than five years of age, all three were aged four years at the time of presentation. [12,13] The tumor distribution and extension is mostly cerebral: Temporal (13), frontal (12), fronto-pariental (1), parietal (6), parietoccipital (6), temporoparietal (2), and occipital (1).…”

Section: Discussionmentioning

confidence: 99%

“…Seizures are more frequent with temporal lesions. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Neuroimaging, both MRI and CT, features of the tumor form differential diagnosis of a cystic lesion with a mural nodule. Size of the lesion is highly variable, 1.0 cm [4] to 9 cm [19] with mean size of 4.7 cm.…”

Section: Discussionmentioning

confidence: 99%

“…Till date approximately 39 cases of PGNTs have been reported in the international literature. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Credit for the first description of PGNT is given to Komori et al who first described a series of nine cases in 1998. [2] The tumor has been assigned a WHO grade I, however aggressive variants have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic diagnosis of a pineal papillary glioneuronal tumor with extensive ventricular involvement: Case report with review of literature

Husain

2009

Neurol India

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Papillary glioneuronal tumor (PGNT) is a newly described mixed glioneuronal tumor, recently included in the World Health Organization classification of central nervous system tumors. We report morphologic and immunohistochemical characteristics PGNT of the pineal region extending into the third and lateral ventricles in a four-year-old male child and reviewed all the cases reported in the international literature till date. In this child the diagnosis of PGNT was established by endoscopic biopsy and squash smear examination.

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“…Calcification may or may not be found. [2][3][4][5][6][7][8] On histology, these tumours characteristically show two different components, namely glial and neuronal as the name itself implies. The neuronal component shows a spectrum that includes mature neurocytes, ganglioid cells and ganglion cells, all staining with neuronal markers such as synaptophysin in a neuropil-rich background.…”

Section: Fig 11mentioning

confidence: 99%

Usefulness of smears in intra‐operative diagnosis of newly described entities of CNS

Varikatt¹,

Dexter²,

Mahajan³

et al. 2009

Neuropathology

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The recent edition of World Health Organisation (WHO) Classification of Tumours of the Central Nervous System has incorporated a substantial number of important changes. It has recognised several new entities, many of which are rare. Intra-operative diagnosis of these tumours can be difficult with the freezing artefact that often cripples brain frozen sections. In many instances intra-operative smears are extremely useful adjuvants in neuropathological diagnosis. In this article, we describe intra-operative smear findings of three of the newly described tumours. Their characteristic cytologic features are illustrated along with differentiating features from the common mimics, together with a general approach to brain smears. The entities we discuss here are papillary glioneuronal tumour, papillary tumour of the pineal region and angiocentric glioma. All three tumours share at least focal pseudo-papillary/vasculocentric architecture. Smears from papillary glioneuronal tumour demonstrated dual population of cells in a neuropil background, whereas papillary tumour of the pineal region and angiocentric glioma comprise a single population of cells. These two tumours can further be differentiated based on their cell morphology and background.

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Papillary glioneuronal tumor radiologically mimicking a cavernous hemangioma with hemorrhagic onset

Cited by 43 publications

References 19 publications

The role of postoperative radiotherapy for the treatment of gangliogliomas

The role of postoperative radiotherapy for the treatment of gangliogliomas

Endoscopic diagnosis of a pineal papillary glioneuronal tumor with extensive ventricular involvement: Case report with review of literature

Usefulness of smears in intra‐operative diagnosis of newly described entities of CNS

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