PAPILLARY TRANSITIONAL CELL TUMOURS, BALKAN NEPHROPATHY, AND Β2-Microglobulin

Survival of the Upper-Urothelial-Cancer Patients from the Balkan Nephropathy Endemic and Nonendemic Areas

“…Frequency of UUT is very high in BN endemic foci [3,8,9], with an occasional extreme clustering of this rare malignancy within a family [10]. Lesions are often multifocal and bilateral [5,7], and pathohistology reveals transitional cell tumors [2], Data on survival of UUT patients from BN endemic areas are scanty, controversial and either methodologi cally dubious [1] or nonnumerical [5,7], This was the reason why we attempted to compare the survival of UUT patients from BN endemic and nonendemic re gions.…”

Balkan endemic nephropathy

“…An exceptionally high frequency of these tumors was also observed in the general population of endemic regions [22]. The attributive risk of developing upper urothelial tumors in inhabitants of endemic foci amounts to several dozen [23] or even to as much as 100-200. There is no evidence that domestic and/or wild animals in endemic regions develop a similar condition.…”