Papular xanthoma: a clinicopathological study of 10 cases

Breier, Friedrich; Zelger, Bettina; Reiter, Harald; Gschnait, F; Zelger, Bernhard

doi:10.1034/j.1600-0560.2002.290402.x

Cited by 51 publications

(31 citation statements)

References 31 publications

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“…Moreover, no initial nonlipidized histiocytic phase can be traced in the early development of the lesions. Staining for factor XIIIa is negative [1, 2]. In our case, the presence of nonfoamy histiocytes in the early lesion and the importance of the inflammatory infiltrate eliminated this diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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Background: Non-Langerhans cell histiocytoses form a heterogeneous group defined by the proliferation of cells with macrophage characteristics. Diagnosis is easy in typical cases but becomes more complex in unusual forms. Case Report: We report the case of a 53-year-old patient who presented multiple brown-to-yellowish papules and nodules of the trunk, neck, and head evolving for 6 months. No visceral involvement was found. Histopathological examination revealed histiocytic proliferation with features of secondary xanthomization with the presence of giant foamy multinucleated Touton cells. One year later, all lesions cleared spontaneously. Based on the clinical presentation and evolution and on the immunohistologic data, we retain the diagnosis of adult xanthogranuloma (AXG) in a diffuse shape. Discussion: Multiple AXG is a rare entity (15 cases reported since 1963) with a stereotypic presentation. It is important to recognize because of its good prognosis and the absence of visceral involvement therefore requiring no investigations or aggressive treatments. This case is interesting because of the complete and spontaneous healing of all the lesions within 20 months.

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Section: Discussionmentioning

confidence: 93%

Multiple Adult Xanthogranuloma: Case Report and Literature Review

et al. 2006

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“…The fixed samples were embedded in paraffin according to Sugiyama et al (1992). Xanthelasma histological diagnosis was based on Breier et al (2002) criteria.…”

Section: Methodsmentioning

confidence: 99%

Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil

et al. 2009

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Xanthelasma might be a clinical manifestation of dyslipidemia, a recognized risk factor for coronary artery disease. We investigated the association of apolipoprotein E (APOE HhaI), apolipoprotein B (APOB XbaI and Ins/Del) and LDL receptor (LDLR AvaII and HincII) gene polymorphisms with lipid profiles in 100 Brazilians with xanthelasma and 100 controls. Allele frequencies were similar in both groups. APOE, APOB and LDLR genotypes were not correlated with differences in the serum lipid profile. In individuals with xanthelasma, the APOB D allele was associated with less chance of having increased LDL-cholesterol (O.R. = 0.16, CI95% = 0.03-0.94, p = 0.042). In the control group, the APOB X+ allele was associated with less chance of having both increased total cholesterol (O.R. = 0.16, CI95% = 0.03-0.78, p = 0.023) and increased LDL-cholesterol (O.R. = 0.10, CI95% = 0.02-0.60, p = 0.012). Moreover, there was a significantly higher frequency of control individuals (68%) with elevated serum triglyceride levels, compared to patients (48%, p = 0.008). On the other hand, triglyceride levels in controls also seemed to be influenced by all other gene polymorphisms studied, an effect that might be enhanced by environmental factors.

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“…[2,4] A series noted positivity for macrophage markers such as KiM1p, CD68, and HAM-56. [7] There are some case reports of PX occurring in association with systemic disorders. Darwin et al have reported a case of generalized PX in a patient with Sezary syndrome.…”

Section: Discussionmentioning

confidence: 98%

Papular xanthoma in a child: Report of a rare entity

Jadhav¹,

Choudhary²,

Ahar³

et al. 2015

Indian J Paediatr Dermatol

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family members including his three younger siblings had similar lesions. The child was otherwise normal except for complaints of occasional low-grade fever. On examination, numerous close set xanthomatous lesions chiefly comprising of flat-topped papules of various sizes, the largest being 7 mm in diameter were seen on face, trunk, back, upper arms, axillae and groin creases. Eyelids were spared, so was the scalp. Few lesions showed central umbilication. The papules were discrete with no tendency to coalesce. There was a line of demarcation just above the buttocks, below which the lesions were conspicuously absent (except a few in popliteal fossae). The papules were firm on palpation and were nontender. Hair, nails, oral and genital mucosa were normal. General examination revealed no abnormality. There was no lymphadenopathy. A differential diagnosis of benign cephalic histiocytosis (BCH) and xanthoma disseminatum were considered. All hematological investigations including the serum lipid profile were normal. Ultrasonography abdomen-pelvis and chest X-ray revealed no abnormalities. Histopathological examination of one of the papules showed a thin epidermis, dense histiocytic infiltrate in the upper and mid dermis with numerous foam cells and a moderate numbers of foamy multinucleate Touton giant cells [ Figure 2a]. The lower epidermis showed mild infiltrate with hyalinization of collagen. Immunohistochemistry showed positive staining for CD68 and was negative for CD1a [ Figure 2b]. ABSTRACTPapular xanthoma (PX) is a form of Non-Langerhan's cell histiocytosis, which is rare and primarily affects adults. Rarely cases have been reported in children as well though the presentation in both the age groups vary considerably. We present a case of PX in a 4½-year-old male child who presented with multiple asymptomatic skin-colored papular lesions on the body.

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Papular xanthoma: a clinicopathological study of 10 cases

Abstract: This series confirms PX as a rare, but distinguished clinicopathologic entity in the spectrum of n-LCH of the skin.

Cited by 51 publications

References 31 publications

Multiple Adult Xanthogranuloma: Case Report and Literature Review

Multiple Adult Xanthogranuloma: Case Report and Literature Review

Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil

Papular xanthoma in a child: Report of a rare entity

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