Papuloerythroderma

Abstract

The main macroscopic features of 4 cases presented here are erythroderma-like lesions and solid papules. The former covers extensive areas over entire trunk and extremities, especially extensor surfaces. The latter is observed mainly on flexor surfaces of extremities and around the former. The axillae, inguinal regions, cubital and popliteal fossae, and big furrows on abdomen are spared from these lesions. Rashes appear first as papules and form erythroderma-like lesions through their assembly and confluence. Histologically, both show almost the same findings. Patients are older males with no general symptoms except itching. Although the course is chronic, lesions improve slowly and heal only after years.

Plasma anaphylatoxin concentrations in inflammatory skin diseases.

“…C3a alone was elevated in the single cases of papuloerythroderma (Ofuji et al 1984), leukocytoclastic vasculitis, toxic erythema, alopecia areata, erythropoietic protoporphyria (EPP), plasma cell cheilitis, or acne vulgaris. In contrast, increase of C4a but not C3a was found in two cases of leukocytoclastic vasculitis, TABLE 1.…”

“…An increase in C3a alone, a sign of alternative pathway activation, was demonstrated in patients showing dermatitic changes, i.e., in those with eczematous dermatitis and in the patient with papuloerythroderma (Ofuji et al 1984). In both of these skin diseases, delayed type hypersensitivity reactions are thought to be responsible for the induction of skin changes.…”

Circumstances that Led to the Definition of Papuloerythroderma (Ofuji) as an Individual Entity

“…Professor Ofuji temporarily named the disorder 'papuloerythroderma syndrome' (introduced in reference 4,5), but it was presented as Papuloerythroderma in Dermatologica (currently, Dermatology) in 1984 (Table 1) [6]. When such reporting began to be made from Europe [2,7], the clinical individuality of this disorder was established [6,8].…”

“…When such reporting began to be made from Europe [2,7], the clinical individuality of this disorder was established [6,8].…”

“…However, Danno [5] conducted additional case studies, and noted a higher incidence of hematopoietic neoplasms among 68 Japanese patients, as it developed in 10 (14.7%), while organ cancer occurred in 16 (23.5%). In the latter, gastric cancer was the most prevalent, developing in [9][10][11][12]. Complications by pulmonary, renal, hepatic, laryngeal, and prostate cancers, squamous cell carcinoma, and angiosarcoma were also reported.…”