Paradigm shifts in multiple sclerosis management: Implications for daily clinical practice

Bourre, Bertrand; Casez, Olivier; Ciron, Jonathan; Guéguen, Antoine; Kwiatkowski, Arnaud; Moisset, Xavier; Montcuquet, Alexis; Ayrignac, Xavier

doi:10.1016/j.neurol.2022.09.006

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Notably, in the presence of complex and heterogeneous data, as happened in MS disease, patient stratification is a strong prerequisite for effective personalized medicine, as disease development is frequently driven by individual variability and unpredictable environmental events [82,83]. Thus, the use of personalized medicine to develop novel therapeutic strategies tailored to the individual patients' characteristics and the specific disease activity features, as well as to the patients' needs and preferences, may bring about novel challenges and perspectives [59,82,83].…”

Section: Multivariate Analysis Of MD Compliance By Adjusting For Pote...mentioning

confidence: 99%

“…There are also diverse modifiable risk factors, such as obesity, lack of exercise, alcohol consumption, and smoking, which may increase the risk of the development and/or management of MS [57,58]. Both modifiable comorbidities and risk factors may differently affect the course and the progression of MS, highlighting the need for more personalized treatment approaches for each MS patient separately [59].…”

Section: Introductionmentioning

confidence: 99%

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Associations between Mediterranean Diet Adherence, Quality of Life, and Mental Health in Patients with Multiple Sclerosis: A Cross-Sectional Study

Dakanalis,

Tryfonos,

Pavlidou

et al. 2024

JPM

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Background: The Mediterranean diet (MD) is well-known as a diet which may exert a protective effect against neurodegenerative diseases, including multiple sclerosis (MS). To date, only a few clinical surveys have assessed the potential effects of the MD in patients with MS. The purpose of the present study is to evaluate the potential effects of MD compliance on disease disability, quality of life, physical activity, depressive symptomatology, and blood biochemical parameters related to nutritional status in MS patients, considering several socio-demographic, anthropometric, and lifestyle characteristics. Methods: This is a cross-sectional study conducted on 558 adults with MS aged 18–64 years. Relevant questionnaires were utilized to evaluate socio-demographic and anthropometric parameters, disease disability (Expanded Disability Status Scale, EDSS), multidimensional health-related quality (MS Quality of Life-54, MSQOL-54), physical activity levels (International Physical Activity Questionnaire, IPAQ), depression (Beck Depression Inventory II, BDI-II), and MD adherence (MedDietScore), while several blood biochemical parameters were retrieved from the patients’ medical records. Results: Enhanced MD compliance was independently associated with a decreased frequency of overweight/obesity, as well as abdominal obesity, in patients suffering from MS. Elevated MD compliance was also independently associated with a decreased incidence of advanced disease disability, a higher prevalence of elevated physical activity, an improved quality of life, and lower depressive symptoms, as well as higher levels of certain blood biochemical parameters, which are effective indicators of iron deficiency and malnutrition. Conclusions: The present study found that higher MD adherence may slow down disease disability, promoting a better quality of life and mental health in adults with MS. Future prospective surveys are required to obtain conclusive results.

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Section: Multivariate Analysis Of MD Compliance By Adjusting For Pote...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between Mediterranean Diet Adherence, Quality of Life, and Mental Health in Patients with Multiple Sclerosis: A Cross-Sectional Study

Dakanalis,

Tryfonos,

Pavlidou

et al. 2024

JPM

View full text Add to dashboard Cite

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Effects of music therapy intervention on gait disorders in persons with multiple sclerosis: A systematic review of clinical trials

Kong

Zhang

Meng

et al. 2023

Multiple Sclerosis and Related Disorders

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Siponimod following Alemtuzumab in secondary progressive MS: investigating sequential therapy–A case series

Zanghì,

Di Filippo,

Avolio

et al. 2024

Multiple Sclerosis and Related Disorders

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Paradigm shifts in multiple sclerosis management: Implications for daily clinical practice

Cited by 6 publications

References 76 publications

Associations between Mediterranean Diet Adherence, Quality of Life, and Mental Health in Patients with Multiple Sclerosis: A Cross-Sectional Study

Associations between Mediterranean Diet Adherence, Quality of Life, and Mental Health in Patients with Multiple Sclerosis: A Cross-Sectional Study

Effects of music therapy intervention on gait disorders in persons with multiple sclerosis: A systematic review of clinical trials

Siponimod following Alemtuzumab in secondary progressive MS: investigating sequential therapy–A case series

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