Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis

Singh, Rohan Bir; Das, Sujata; Chodosh, James; Sharma, Namrata; Zegans, Michael E.; Kowalski, Regis P.; Jhanji, Vishal

doi:10.1016/j.preteyeres.2021.101028

Cited by 28 publications

(39 citation statements)

References 575 publications

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“…The cornea is a critical component of the visual system, [1][2][3][4] and its susceptibility to bacteria, such as Staphylococcus, Streptococcus, Streptococcus, and Pseudomonas, can easily cause corneal infection and lead to irreversible visual damage if not adequately treated. [5][6][7] Current treatments for keratitis generally focus on bacterial eradication and tissue repair. While antibiotic eye drops are commonly employed, they suffer from limitations such as poor bioavailability and the potential to foster antibioticresistant strains of bacteria.…”

Section: Introductionmentioning

confidence: 99%

Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Kong,

Liu,

et al. 2023

Adv Funct Materials

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Biomedical patches offer significant potential for keratitis treatment. Building on advances in multifunctionality and biomimicry, an innovative, multifunctional hydrogel patch with high therapeutic efficacy, inspired by the native architecture and functions of the cornea, is introduced. By engineering a composite patch comprising recombinant human collagen (RHC) hydrogel, near‐field electrospinning (NFES) microfibers, and gold‐nanoparticle‐decorated tetragonal barium titanates (BTO@Au), structural mimicry, mechanical reinforcement, tissue‐specific adhesion, and bacterial inhibition are achieved. The RHC hydrogel recreates a three‐dimensional (3D) microenvironment that emulates the natural structure of the corneal tissue, demonstrating excellent tissue adhesion. Integrated within this hydrogel, the NFES microfibers, designed to emulate the orthogonal arrangement of native corneal stroma, not only reinforce the mechanical strength of the RHC hydrogel but also act as scaffolds to guide the aligned growth of human keratocytes. A unique aspect of this advanced patch is the incorporation of BTO@Au nanoparticles, which generate reactive oxygen species for effective bacterial eradication when subjected to ultrasound stimulation. Through in vivo studies on rat models with infected corneal wounds, this hydrogel patch exhibits superior therapeutic efficacy compared to the current treatment. It is posited that these cornea‐inspired ultrasound‐responsive adhesive hydrogel patches represent a significant scientific advancement with high potential for clinical applications.

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Section: Introductionmentioning

confidence: 99%

Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Kong,

Liu,

et al. 2023

Adv Funct Materials

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“…Целью настоящей работы явился анализ современных представлений о бактериальных кератитах с акцентом на методах их диагностики [5][6][7][8].…”

Section: Introductionunclassified

Bacterial Keratitis. Part 1. Epidemiology, Etiology, Pathophysiology, Risk Factors, Clinic, Current Aspects of Diagnosis

et al. 2023

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Bacterial keratitis is an urgent problem in ophthalmology, representing a threatening condition for the anatomy and function of the eyeball. The disease is widespread and varies significantly depending on the geographical region, even within the same country. The BC clinic is well-known, has been studied in sufficient detail, but in real practice it often causes significant difficulties in diagnosis, since it largely resembles a keratitis clinic of another etiology. A significant role in the differential diagnosis of these diseases is played by laboratory tests, which are not always available and easy to perform and implement. The results of the bacteriological analysis have a delayed period, which may be critical for determining the correct treatment tactics, but, nevertheless, the information that can be obtained about the microbe and its sensitivity to ABP makes it possible to better cope with the infectious process. The development and introduction of new laboratory research methods into modern clinical practice is very relevant, could simplify and speed up the diagnosis of the disease, and with it increase the effectiveness of its treatment.

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“…This creates an opportunity to avail from an international pool of talent and diverse experiences serving an impetus to organisational productivity. It also creates a huge challenge for the management; putting their expertise to the test (Singh et al, 2022). Given the similarity of beliefs, cultures and traditions, it is easier to manage personnel of homogeneous or local strata.…”

Section: Introductionmentioning

confidence: 99%

Stay or not to Stay: An Analysis of Diversity Management and Abusive Leadership Relationship with Turnover Intention

Arif

Ahmed

2023

JISR-MSSE

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With the emergence of economic globalisation, HR executives strive to provide a fairer working environment as there is an unprecedented shift of increased participation of people with diﬀerent demographic backgrounds, genders and belief systems at workplaces around the globe. Simultaneously, there has been a tremendous rise in the occurrences of abusive leadership behaviours leading to increased turnover ratios. Hence, this study aims to investigate the eﬀects of abusive leadership and diversity management practices on turnover intention. This study data has been collected from the employees of pharmaceutical companies based in Karachi, Pakistan using a non- probability purposive sampling technique. Data was taken from (n = 403) participants. The results show a signiﬁcant negative relationship between diversity management and turnover intention and a signiﬁcant positive relationship between abusive leadership and turnover intention. The results also indicate that job satisfaction mediates the relationship of both diversity management and abusive leadership with turnover intention. The study emphasises that organisations should consciously channel their resources eﬀectively into creating an all-inclusive environment to cater the psychological needs of a diverse workforce. The study also implicated that organisational leadership should pay special attention to ensure that they treat their subordinates fairly across the board, as the behaviour of the leaders has far-reaching eﬀects on the performance, productivity and psychological well-being of the employees.

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Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis

Cited by 28 publications

References 575 publications

Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Bacterial Keratitis. Part 1. Epidemiology, Etiology, Pathophysiology, Risk Factors, Clinic, Current Aspects of Diagnosis

Stay or not to Stay: An Analysis of Diversity Management and Abusive Leadership Relationship with Turnover Intention

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