Paradoxical reactions during Antituberculosis therapy - A single-center prospective analysis

Abstract

Background: Paradoxical reactions during anti-TB treatment represent a real challenge to pneumo-phthisiologists and require high index of suspicion. It has been suggested that this reaction during appropriate treatment is common and severe in HIVnegative individuals. Our objective was to determine the frequency of paradoxical reactions and their associated features. Method : A prospective study was undertaken in a population of HIV-TB+ patients to determine the frequency of paradoxical reactions and their associated features. Results: Paradoxical reactions occurred in 1.5% of all our hospital's TB patients. Conclusion : Paradoxical reactions during anti-TB treatment is common in HIV-uninfected individuals and must be considered after careful exclusion of medication non-adherence, other infections, development of resistance, and other similar conditions.