Parallel Hippocampal-Parietal Circuits for Self- and Goal-oriented Processing

Zheng, Annie; Montez, David F.; Marek, Scott; Gilmore, Adrian W.; Newbold, Dillan J.; Laumann, Timothy O.; Kay, Benjamin P.; Seider, Nicole A.; Van, Andrew N.; Hampton, Jacqueline M.; Alexopolous, Dimitrios; Schlaggar, Bradley L.; Greene, Deanna J.; Shimony, Joshua S.; Nelson, Steven M.; Wig, Gagan S.; Gratton, Caterina; McDermott, Kathleen B.; Raichle, Marcus E.; Gordon, Evan M.; Dosenbach, Nico U.F.

doi:10.1101/2020.12.01.395210

Cited by 11 publications

(12 citation statements)

References 103 publications

(203 reference statements)

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“…OPEN ACCESS functional interactions, namely resting-state connectivity [15,53,54], as illustrated in Figure 1. This organizational dimension hence reflects the differential functional integration into whole-brain networks of hippocampal anterior and posterior regions, as illustrated in Figure 2 (see also [55]).…”

Section: Trends In Neurosciencesmentioning

confidence: 97%

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The many dimensions of human hippocampal organization and (dys)function

Genon

Bernhardt

Joie

et al. 2021

Trends in Neurosciences

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Section: Trends In Neurosciencesmentioning

confidence: 97%

“…This pattern, in line with its local microstructural origin, is assumed to serve local information-processing flows possibly corresponding to different processing requirements at the macroscale. In turn, the long-axis organizational pattern maps more directly into brain large-scale behavioral systems [55].…”

Section: Open Accessmentioning

confidence: 99%

The many dimensions of human hippocampal organization and (dys)function

Genon

Bernhardt

Joie

et al. 2021

Trends in Neurosciences

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“…The central role of the hippocampus for orchestrating goal-oriented behavior is further suggested by its involvement in “vicarious trial-and-error” behavior [ 138 ], as well as by the centrality of theta rhythms for intentional control [ 126 , 131 , 139 , 140 ]. Additional supporting evidence can be found in hippocampally-mediated orchestration of counterfactual inferences in other domains, ranging from predictive information over likely trajectories for locomoting rodents [ 141 , 142 ] to the simulation of alternative perspectives by imagining humans [ 143 , 144 ].…”

Section: From Action To Attention and Back Againmentioning

confidence: 98%

The Radically Embodied Conscious Cybernetic Bayesian Brain: From Free Energy to Free Will and Back Again

Safron

2021

Entropy

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Drawing from both enactivist and cognitivist perspectives on mind, I propose that explaining teleological phenomena may require reappraising both “Cartesian theaters” and mental homunculi in terms of embodied self-models (ESMs), understood as body maps with agentic properties, functioning as predictive-memory systems and cybernetic controllers. Quasi-homuncular ESMs are suggested to constitute a major organizing principle for neural architectures due to their initial and ongoing significance for solutions to inference problems in cognitive (and affective) development. Embodied experiences provide foundational lessons in learning curriculums in which agents explore increasingly challenging problem spaces, so answering an unresolved question in Bayesian cognitive science: what are biologically plausible mechanisms for equipping learners with sufficiently powerful inductive biases to adequately constrain inference spaces? Drawing on models from neurophysiology, psychology, and developmental robotics, I describe how embodiment provides fundamental sources of empirical priors (as reliably learnable posterior expectations). If ESMs play this kind of foundational role in cognitive development, then bidirectional linkages will be found between all sensory modalities and frontal-parietal control hierarchies, so infusing all senses with somatic-motoric properties, thereby structuring all perception by relevant affordances, so solving frame problems for embodied agents. Drawing upon the Free Energy Principle and Active Inference framework, I describe a particular mechanism for intentional action selection via consciously imagined (and explicitly represented) goal realization, where contrasts between desired and present states influence ongoing policy selection via predictive coding mechanisms and backward-chained imaginings (as self-realizing predictions). This embodied developmental legacy suggests a mechanism by which imaginings can be intentionally shaped by (internalized) partially-expressed motor acts, so providing means of agentic control for attention, working memory, imagination, and behavior. I further describe the nature(s) of mental causation and self-control, and also provide an account of readiness potentials in Libet paradigms wherein conscious intentions shape causal streams leading to enaction. Finally, I provide neurophenomenological handlings of prototypical qualia including pleasure, pain, and desire in terms of self-annihilating free energy gradients via quasi-synesthetic interoceptive active inference. In brief, this manuscript is intended to illustrate how radically embodied minds may create foundations for intelligence (as capacity for learning and inference), consciousness (as somatically-grounded self-world modeling), and will (as deployment of predictive models for enacting valued goals).

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“…2005 ; Buckner and DiNicola 2019 ). Recent studies have proposed that the ventral precuneus also has functional subdivisions, with the rostral ventral belonging to DMN proper and the caudal ventral belonging to the parietal episodic memory network ( Zheng et al. 2020 ).…”

Section: Consciousness As Such—nondual Awarenessmentioning

confidence: 99%

Implicit–explicit gradient of nondual awareness or consciousness as such

Josipovic

2021

Neuroscience of Consciousness

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Consciousness is multi-dimensional but is most often portrayed with a two-dimensional (2D) map that has global levels or states on one axis and phenomenal contents on the other. On this map, awareness is conflated either with general alertness or with phenomenal content. This contributes to ongoing difficulties in the scientific understanding of consciousness. Previously, I have proposed that consciousness as such or nondual awareness—a basic non-conceptual, non-propositional awareness in itself free of subject-object fragmentation—is a unique kind that cannot be adequately specified by this 2D map of states and contents. Here, I propose an implicit–explicit gradient of nondual awareness to be added as the z-axis to the existing 2D map of consciousness. This gradient informs about the degree to which nondual awareness is manifest in any experience, independent of the specifics of global state or local content. Alternatively, within the multi-dimensional state space model of consciousness, nondual awareness can be specified by several vectors, each representing one of its properties. In the first part, I outline nondual awareness or consciousness as such in terms of its phenomenal description, its function and its neural correlates. In the second part, I explore the implicit–explicit gradient of nondual awareness and how including it as an additional axis clarifies certain features of everyday dualistic experiences and is especially relevant for understanding the unitary and nondual experiences accessed via different contemplative methods, mind-altering substances or spontaneously.

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Parallel Hippocampal-Parietal Circuits for Self- and Goal-oriented Processing

Cited by 11 publications

References 103 publications

The many dimensions of human hippocampal organization and (dys)function

The many dimensions of human hippocampal organization and (dys)function

The Radically Embodied Conscious Cybernetic Bayesian Brain: From Free Energy to Free Will and Back Again

Implicit–explicit gradient of nondual awareness or consciousness as such

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