Parallel optical read-out of micromechanical pillars applied to prostate specific membrane antigen detection

Tardivo, Martina; Toffoli, Valeria; Fracasso, Giulio; Borin, Daniele; Zilio, Simone Dal; Colusso, Andrea; Carrato, Sergio; Scoles, G.; Meneghetti, Moreno; Colombatti, Marco; Lazzarino, Marco

doi:10.1016/j.bios.2015.05.026

Cited by 16 publications

(9 citation statements)

References 26 publications

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“…The fabricated immunosensor was successfully used for detecting Immunoglobin (IgG) and anti-IgG in human serum with very low LOD. In another example, Tardivo et al [ 29 ] reported a sensor having thousands of micropillars and columnar resonators arranged in an area of 1 mm square. The sensing was done using image and software analysis capturing images at 15 fps.…”

Section: Types Of Biosensorsmentioning

confidence: 99%

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Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope

et al. 2021

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The electrochemical biosensors are a class of biosensors which convert biological information such as analyte concentration that is a biological recognition element (biochemical receptor) into current or voltage. Electrochemical biosensors depict propitious diagnostic technology which can detect biomarkers in body fluids such as sweat, blood, feces, or urine. Combinations of suitable immobilization techniques with effective transducers give rise to an efficient biosensor. They have been employed in the food industry, medical sciences, defense, studying plant biology, etc. While sensing complex structures and entities, a large data is obtained, and it becomes difficult to manually interpret all the data. Machine learning helps in interpreting large sensing data. In the case of biosensors, the presence of impurity affects the performance of the sensor and machine learning helps in removing signals obtained from the contaminants to obtain a high sensitivity. In this review, we discuss different types of biosensors along with their applications and the benefits of machine learning. This is followed by a discussion on the challenges, missing gaps in the knowledge, and solutions in the field of electrochemical biosensors. This review aims to serve as a valuable resource for scientists and engineers entering the interdisciplinary field of electrochemical biosensors. Furthermore, this review provides insight into the type of electrochemical biosensors, their applications, the importance of machine learning (ML) in biosensing, and challenges and future outlook.

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Section: Types Of Biosensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope

et al. 2021

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“…These highlights make biosensors appropriate for point-of-care diagnostics because they can achieve quick and multi-analyte detection [67]. There are different types of biosensors including optical [68,69], electrochemical [70,71], piezoelectric [72,73], magnetic [74,75], micromechanical [76,77], and thermal [78,79,80,81] for medical diagnosis.…”

Section: Principle Of Biosensormentioning

confidence: 99%

An Alternative Medical Diagnosis Method: Biosensors for Virus Detection

et al. 2019

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Infectious diseases still pose an omnipresent threat to global and public health, especially in many countries and rural areas of cities. Underlying reasons of such serious maladies can be summarized as the paucity of appropriate analysis methods and subsequent treatment strategies due to the limited access of centralized and equipped health care facilities for diagnosis. Biosensors hold great impact to turn our current analytical methods into diagnostic strategies by restructuring their sensing module for the detection of biomolecules, especially nano-sized objects such as protein biomarkers and viruses. Unquestionably, current sensing platforms require continuous updates to address growing challenges in the diagnosis of viruses as viruses change quickly and spread largely from person-to-person, indicating the urgency of early diagnosis. Some of the challenges can be classified in biological barriers (specificity, low number of targets, and biological matrices) and technological limitations (detection limit, linear dynamic range, stability, and reliability), as well as economical aspects that limit their implementation into resource-scarce settings. In this review, the principle and types of biosensors and their applications in the diagnosis of distinct infectious diseases were comprehensively explained. The deployment of current biosensors into resource-scarce settings is further discussed for virus detection by elaborating the pros and cons of existing methods as a conclusion and future perspective.

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“…The system has been tested for IgG detecting anti-IgG into human serum with detection limit of the order of tens of micrograms per liter. A further example can be represented by the use of micro-pillars, columnar resonators that can be arranged in dense arrays of several thousand sensors in a squared mm, as reported by Tardivo et al [61]. The authors propose a detection method based on CCD imaging and software image analysis, which can measure the resonance frequency of tens of pillars in parallel.…”

Section: Biosensorsmentioning

confidence: 99%

Chemical Sensors and Biosensors in Italy: A Review of the 2015 Literature

Compagnone

Francia

Natale

et al. 2017

Sensors

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The contributions of Italian researchers to sensor research in 2015 is reviewed. The analysis of the activities in one year allows one to obtain a snapshot of the Italian scenario capturing the main directions of the research activities. Furthermore, the distance of more than one year makes meaningful the bibliometric analysis of the reviewed papers. The review shows a research community distributed among different scientific disciplines, from chemistry, physics, engineering, and material science, with a strong interest in collaborative works.

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Parallel optical read-out of micromechanical pillars applied to prostate specific membrane antigen detection

Cited by 16 publications

References 26 publications

Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope

Recent Advances in Electrochemical Biosensors: Applications, Challenges, and Future Scope

An Alternative Medical Diagnosis Method: Biosensors for Virus Detection

Chemical Sensors and Biosensors in Italy: A Review of the 2015 Literature

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