A new electronic speckle pattern interferometry method is proposed to realize in situ deformation measurements. The feature of the method is the combination of a high-speed camera and multiple laser Doppler vibrometers (LDVs) for synchronous measurements. The high-speed camera is used to record and select effective interferograms, while the LDVs are used to measure the rigid body displacement caused by vibrations. A series of effective interferograms with known shifted phase values are obtained to calculate the deformation phase. The experimental results show that the method performs well in measuring static and dynamic deformations with high accuracy in vibrating environments.