Parallelism as a Novel Marker for Structural Integrity of Retinal Layers in Optical Coherence Tomographic Images in Eyes With Epiretinal Membrane

Uji, Akihito; Murakami, Tomoaki; Unoki, Noriyuki; Ogino, Ken; Nishijima, Kazuaki; Yoshitake, Shin; Dodo, Yoko; Yoshimura, Nagahisa

doi:10.1016/j.ajo.2013.09.008

Cited by 25 publications

(18 citation statements)

References 37 publications

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“…Recently, Uji and associates successfully applied a quantitative evaluation to the foveal pathomorphology of eyes with an epiretinal membrane24 or diabetic macular edema25 using OCT imaging. In the present study, parallelism was used in the analysis of hemorrhagic patterns on color fundus photography.…”

Section: Discussionmentioning

confidence: 99%

“…Uji and associates recently reported a new method of “parallelism” to quantitatively evaluate foveal pathomorphologies of eyes with an epiretinal membrane24 or diabetic macular edema25. Parallelism can be calculated using line segments after simple filtering and thresholding of the original images, and reflects how parallel and linearly objects lie side-by-side2223.…”

Section: Methodsmentioning

confidence: 99%

“…3). Parallelism was calculated using a modified version of the previously described method for OCT image analyses2425. Briefly, skeletonized images (lines) were extracted from cropped Optos images by applying a 4–5 pixel band-pass filter using ImageJ software (Wayne Rasband, National Institutes of Health, Bethesda, MD, USA; available at http://rsb.info.nih.gov/ij/index.html) and the Kbi_BandPass plug-in (http://hasezawa.ib.k.u-tokyo.ac.jp/zp/Kbi/ImageJKbiPlugins) followed by binarization with intensity thresholding using Otsu’s thresholding method for automatic binarization level decisions using the Kbi_ThrOtsu plug-in (http://hasezawa.ib.k.u-tokyo.ac.jp/zp/Kbi/ImageJKbiPlugins).…”

Section: Methodsmentioning

confidence: 99%

“…where n 0 , n 45 , n 90 , and n 135 are the numbers of neighboring pixel pairs at 0°, 45°, 90°, and 135° with respect to the horizon, respectively2425. Parallelism can range from 0 to 1, and images with more parallel line segments have higher parallelism.…”

Section: Methodsmentioning

confidence: 99%

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Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion

Muraoka

Uji

Tsujikawa

et al. 2016

Sci Rep

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This prospective study included 63 eyes with acute branch retinal vein occlusion (BRVO) to evaluate the retinal hemorrhagic patterns at the posterior poles and explore their clinical relevance in macular perfusion differentiation. Retinal hemorrhagic patterns and macular perfusion status were evaluated via fundus photography and fluorescein angiography, respectively. Macular perfusion was judged as nonischemic in 30, ischemic in 28, and undeterminable in 5 among the 63 eyes. Predominant hemorrhagic patterns were flame-shaped in 39 (67.2%) and non-flame-shaped in 19 (32.8%) eyes. All 39 eyes with a flame-shaped hemorrhage showed a nonischemic macula. Of the 19 eyes classified as having a non-flame-shaped hemorrhage, 13 (68.4%) had an ischemic macula and 6 (31.6%) had a nonischemic macula (P < 0.001). Parallelism in eyes with a flame-shaped hemorrhage was higher than in those with a non-flame-shaped hemorrhage (P < 0.001), and in those with a nonischemic macula versus those with an ischemic macula (P < 0.001). The area under the curve for parallelism was 0.975 (P < 0.001), suggesting an accurate diagnostic parameter for macular perfusion differentiation. In conclusion, we objectively evaluated retinal hemorrhagic patterns at the posterior pole in BRVO using the parallelism method, which was useful in differentiating macular perfusion status.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion

Muraoka

Uji

Tsujikawa

et al. 2016

Sci Rep

Self Cite

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“…The more parallel the retinal layers, the better the visual acuity. Parallelism is also documented to significantly correlate with metamorphosia [69]. …”

Section: Biomarkers In Disorders Of the Vitreomacular Interfacementioning

confidence: 99%

The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

et al. 2017

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BackgroundBiomarker”, a merged word of “biological marker”, refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases.Main bodySpectral domain optical coherence tomography imaging-based biomarkers provide a valuable tool for detecting the earlier stages of the disease, tracking progression, and monitoring treatment response. The aim of this review article is to analyze various OCT based imaging biomarkers and their potential to be considered as surrogate endpoints for diabetic retinopathy, age related macular degeneration, retinitis pigmentosa and vitreomacular interface disorder. These OCT based surrogate markers have been classified as retinal structural alterations (macular central subfield thickness and cube average thickness); retinal ultrastructural alterations (disruption of external limiting membrane and ellipsoid zone, thinning of retinal nerve fiber layer and ganglion cell layer); intraretinal microangiopathic changes; choroidal surrogate endpoints; and vitreoretinal interface endpoints.ConclusionOCT technology is changing very quickly and throughout this review there are some of the multiple possibilities that OCT based imaging biomarkers will be more useful in the near future for diagnosis, prognosticating disease progression and as endpoint in clinical trials.

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Spectral Domain Optical Coherence Tomography-Based Imaging Biomarkers and Hyperspectral Imaging

Ruia

Saxena

2016

Spectral Domain Optical Coherence Tomography in Macular Diseases

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Parallelism as a Novel Marker for Structural Integrity of Retinal Layers in Optical Coherence Tomographic Images in Eyes With Epiretinal Membrane

Cited by 25 publications

References 37 publications

Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion

Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion

The potential of spectral domain optical coherence tomography imaging based retinal biomarkers

Spectral Domain Optical Coherence Tomography-Based Imaging Biomarkers and Hyperspectral Imaging

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