Paramagnetic species in the plasma of dogs with lymphoma prior to and after treatment with doxorubicin

Gille, Lars; Kleiter, Miriam; Willmann, Michael; Nohl, Hans

doi:10.1016/s0006-2952(02)01416-8

Cited by 14 publications

(10 citation statements)

References 30 publications

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“…Based on the result, it can be concluded that doxorubicin is not only cytotoxic against all the human cancer cell lines tested, but also the non-cancer human cell line. This result supports the statement that doxorubicin is a potent cytostatic drug which is applied for the treatment of cancer diseases but the routine use of this drug could bring major adverse effect [24]. Although the cytotoxicity of the isolated compounds and mixture of Pereskia bleo are not as effective as doxorubicin, they however have low toxicity against normal MRC5 cell line in comparison to doxorubicin.…”

Section: Resultssupporting

confidence: 82%

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Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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Dihydroactinidiolide (1) and a mixture of sterols [campesterol (2), stigmasterol (3) and β-sitosterol (4)], together with the previously isolated individual compounds β-sitosterol (4), 2,4-di-tert-butylphenol (5), α-tocopherol (6), phytol (7) were isolated from the active ethyl acetate fraction of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Cytotoxic activities of the above mentioned compounds against five human carcinoma cell lines, namely the human nasopharyngeal epidermoid carcinoma cell line (KB), human cervical carcinoma cell line (CasKi), human colon carcinoma cell line (HCT 116), human hormone-dependent breast carcinoma cell line (MCF7) and human lung carcinoma cell line (A549); and non-cancer human fibroblast cell line (MRC-5) were investigated. Compound 5 possessed very remarkable cytotoxic activity against KB cells, with an IC50 value of 0.81µg/mL. This is the first report on the cytotoxic activities of the compounds isolated from Pereskia bleo.

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Section: Resultssupporting

confidence: 82%

“…Doxorubicin which is clinically used for the treatment of a great variety of cancer disease [24,25,26] was used as the positive control in present study. Based on the result, it can be concluded that doxorubicin is not only cytotoxic against all the human cancer cell lines tested, but also the non-cancer human cell line.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

et al. 2009

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“…4). According to literature data and due to the high content of vitamin C confirmed by HPLC analysis (Table 2), this can be assigned to an ascorbyl radical [18,36]. It has been reported that the reaction of ascorbic acid with more aggressive radicals results in the production of an intermediate radical, ascorbyl, of low reactivity.…”

Section: Superoxide Anion Radical Scavenging Activity Of Bilberry Extmentioning

confidence: 82%

Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.)

Tumbas

Čanadanović-Brunet

Gille

et al. 2010

Journal of Berry Research

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Naturally occurring antioxidants present in bilberry were separated into three groups: vitamin C, phenolic acids and flavonoids using solid phase extraction (SPE). Chemical composition of bilberry extract fractions was obtained by spectrophotometry and high performance liquid chromatography (HPLC). The results of HPLC analysis point out the high content of vitamin C (1529 g/g) in fraction Fr1, flavonoids (1328.58 g/g) in fraction Fr2 and phenolic acids (494.31 g/g) in fraction Fr3. The free radical scavenging activities of these antioxidant fractions on superoxide anion radicals and detection of free radical intermediates was studied using electron spin resonance (ESR) spectroscopy. Superoxide anion free radical assay demonstrated very potent free radical scavenging activity of bilberry extract fractions. The results of correlation analysis showed that the separated classes of antioxidants from bilberry (vitamin C, flavonoids and phenolic acids) are responsible for its antioxidant activity.

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“…Antioxidant properties were long considered to be the major or even sole determinants for efficient protectors against doxorubicin cardiotoxicity because reactive oxygen species and oxidative stress are considered to be involved in the pathophysiology of its development [31,32,33]. However, it has been shown that there are pronounced differences in the cardioprotective effects also among the flavonoids with comparable antioxidant properties [6].…”

Section: Discussionmentioning

confidence: 99%

Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

Kaiserová

Šimůnek²,

Vijgh³

et al. 2007

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

106

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Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use is limited by the dose-dependent cardiotoxicity. Flavonoids represent a potentially attractive class of compounds to mitigate the anthracycline cardiotoxicity due to their iron-chelating, antioxidant and carbonyl reductase-inhibitory effects. The relative contribution of various characteristics of the flavonoids to their cardioprotective activity is, however, not known. A series of ten flavonoids including quercetin, quercitrin, 7-monohydroxyethylrutoside (monoHER) and seven original synthetic compounds were employed to examine the relationships between their inhibitory effects on carbonyl reduction, iron-chelation and antioxidant properties with respect to their protective potential against doxorubicin-induced cardiotoxicity. Cardioprotection was investigated in the neonatal rat ventricular cardiomyocytes whereas the H9c2 cardiomyoblast cells were used for cytotoxicity testing. Iron chelation was examined via the calcein assay and antioxidant effects and site-specific scavenging were quantified by means of inhibition of lipid peroxidation and hydroxyl radical scavenging activity, respectively. Inhibition of carbonyl reductases was assessed in cytosol from human liver. None of the flavonoids tested had better cardioprotective action than the reference cardioprotector, monoHER. However, a newly synthesized quaternary ammonium analog with comparable cardioprotective effects has been identified. No direct correlation between the iron-chelating and/or antioxidant effect and cardioprotective potential has been found. A major role of carbonyl reductase inhibition seems unlikely, as the best two cardioprotectors of the series are only weak reductase inhibitors.

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Paramagnetic species in the plasma of dogs with lymphoma prior to and after treatment with doxorubicin

Cited by 14 publications

References 30 publications

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Cytotoxic Components of Pereskia bleo (Kunth) DC. (Cactaceae) Leaves

Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.)

Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

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