Parameters Affecting Absorption of Griseofulvin in a Human Subject Using Urinary Metabolite Excretion Data

Kabasakalian, Peter; Katz, Micaela; Rosenkrantz, Bernard; Townley, Edward R.

doi:10.1002/jps.2600590504

Cited by 60 publications

(17 citation statements)

References 24 publications

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“…While the absorption of atenolol is reduced by food (Melander et aI., 1979b), and that of metoprolol and propranolol is increased (Melander et aI., 1977d), plasma concentrations of oxprenolol are unaffected by food whether it is taken as conventional or slow-release tablets (Dawes et a!., 1979). It is not clear whether this is due to the intrinsic properties of the compound, or to the different Reference Welling et al (1980) Melander et al (1977c) Levyet al (1975 Welling and ) Welling et al (1975b) Melander and Wahlin (1978) Tenconi et al (1977) Crounse (1961; Kabasakalian et al (1970) Melander et al (1977b Beerman and Groschinsky-Grind (1978b) Mantyla et al (1980) Jeppson and Sjogren (1975) Munst et al (1980) Ehrsson et al (1979) Melander et al (1977d) Bates et al (1974; Rosenberg and Bates (1976);Mannisto (1978). Melander (1979a) Jordan et al (1981) Melander et al (1977d) Ohnhaus (1980 Levy and Jusko (1966) Levy (1967) Kaumeier (1979); Kaumeier et al (1979) Hasegawa et al (1981 methodologies used in the various studies.…”

Section: Interactions Having No Effect On Drug Absorptionmentioning

confidence: 99%

Interactions Affecting Drug Absorption

Welling¹

1984

Clinical Pharmacokinetics

158

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The influence of drug-drug and drug-food interactions affecting the absorption of orally administered medication is reviewed. Drug-drug interactions can be classified in terms of indirect effects by one drug on gastrointestinal tract physiology influencing the absorption of other drugs, or direct interactions involving altered pH, adsorption, absorption, or chelation. Most, but not all, drug-drug interactions result in reduced or delayed systemic drug availability. Drug-food interactions may result in reduced, delayed, or increased systemic drug availability. The absorption of only a small number of drugs is unaffected by concomitant food intake. The degree of interaction and whether it positively or negatively affects drug absorption depends on a number of factors including the physical and chemical nature of the drug, the formulation, the type of meal, and the time interval between eating and dosing. Mechanisms of drug-food interactions are not well characterised. They clearly involve both direct and indirect factors in a similar fashion to drug-drug interactions, but indirect factors probably predominate. Reduced or delayed drug absorption is generally attributed, at least in part, to delayed stomach-emptying due to food. Increased absorption may also result from delayed stomach-emptying facilitating greater drug dissolution before it passes from the stomach into the small intestine. Increased bioavailability of some drugs, e.g. propranolol, metoprolol and labetalol, may be related to reduced presystemic clearance. The potential clinical implications of drug-drug and drug-food interactions must be taken into account with oral medications in order to minimise variations in systemic drug availability and hence in clinical efficacy.

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Section: Interactions Having No Effect On Drug Absorptionmentioning

confidence: 99%

Interactions Affecting Drug Absorption

Welling¹

1984

Clinical Pharmacokinetics

158

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“…In the degradation of hetacillin (I) in aqueous solution, at least two reactions are possible: hydrolytic interconversion to ampicillin (11) (2, 3) and epimerization to 6epihetacillin (111) (4), which produces inactive 6-epiampicillin (5). The rates of both hydrolysis (2,3,6) and epimerization (7) depend on pH and occur simultaneously (Scheme I).…”

Section: Hydrolysis and Epimerization Kinetics Of Hetacillin In Aqueomentioning

confidence: 99%

Effect of Sleep on Bioavailability of Tetracycline

Adir

Barr²

1977

Journal of Pharmaceutical Sciences

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“…Accordingly, in 1967, the Department of Health, Education, and Welfare's Task Force on Prescription Drugs recommended to the Food and Drug Administration that bioavailability studies be initiated on griseofulvin products (4). However, to date, bioavailability information only exists for drug products manufactured by the three major producers (5)(6)(7)(8)(9)(10). To our knowledge, the literature is devoid of such information for any of the numerous generic products currently on the market.…”

Section: To the Editormentioning

confidence: 99%