Parameters and outcomes in 525 patients operated on for oral squamous cell carcinoma

Garzino-Demo, Paolo; Zavattero, Emanuele; Franco, Pierfrancesco; Fasolis, Massimo; Tanteri, Giulia; Mettus, A.; Tosco, Paolo; Chiusa, Luigi; Airoldi, Mario; Ostellino, O.; Schena, Marina; Rampino, Monica; Ricardi, Umberto; Evangelista, Andrea; Merletti, Franco; Berrone, Sid; Ramieri, Guglielmo

doi:10.1016/j.jcms.2016.06.007

Cited by 38 publications

(32 citation statements)

References 57 publications

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“…And there was tendency to associated with alcohol consumption (P=0.08). Our finding that the N classification predicts poor survival is reasonable, and is consistent with previous reports of the clinical significance of cervical lymph-node metastasis [14][15][16]. Our results also agree with many reports on the association between alcohol consumption and mortality and carcinogenesis, and with other reports indicating that alcohol is related to a poor prognosis [17][18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 93%

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Hirohata¹,

Yanagawa²,

Takaoka³

et al. 2018

J Dents Dent Med

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Background: Synaptic adhesion molecules regulate synapse development and maintenance. Neurexins and neuroligins have been implicated in psychiatric disorders, and shown that they are related to vascular system and carcinomas in recent studies. In the present study we focused neurexin 1 and neuroligin1, and investigated the relationship between those two molecules expression and clinical features of oral cancer. Materials and methods: Fifty-six biopsy samples from oral squamous cell carcinomas (OSCCs) were analyzed semi quantitatively by immunohistochemistry. Correlations between the expression level of neurexin 1, neuroligin 1, p53, Ki67 and the clinical features of OSCCs were statistically analyzed. Results: The neurexin 1 expression group contained significantly advanced T (P < 0.05) and N classification positive cases (P < 0.01) by univariate analysis. Overall survival was compared with Kaplan-Meier analysis and the log rank statistic. The prognosis of neuroligin 1 expression group was significantly more favorable (P < 0.05). A Cox proportional hazards model was used to test the significance of survival time, and N classification positive (P < 0.05), neurexin 1 (P < 0.05) and neuroligin 1 (P < 0.01) were predictive factor for survival. Conclusions: Synaptic adhesive molecule could be useful prognosis factor for OSCC and may help to determine therapeutic policy.

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Section: Discussionsupporting

confidence: 93%

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Hirohata¹,

Yanagawa²,

Takaoka³

et al. 2018

J Dents Dent Med

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“…However, a correlation was detected between the Bmi-1 expression and the histopathological grading in the studied samples -the higher the Bmi-1 expression, the lower the degree of histopathological differentiation of the OSCC. The degree of histological differentiation is directly related to patient prognosis, i.e., the lower the degree of histological differentiation the more aggressive the tumor is (21). The literature reports that Bmi-1 expression in bladder tumors, wherein the higher expression of Bmi-1 protein also provided a lower degree of differentiation, increased risk of recurrence and worse prognosis, confirming our results in relation to Bmi-1 expression in poorly differentiated tumors (22).…”

Section: Discussionsupporting

confidence: 89%

Analysis of the Epithelium-Mesenchymal Transition Process on Oral Squamous Cell Carcinomas

et al. 2017

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The aim of this study is to evaluate the immunohistochemical expression of E-cadherin, N-cadherin and Bmi-1, and their association with clinical parameters and with the degree of histopathological differentiation in oral squamous cell carcinomas. 65 squamous cell carcinoma samples were used for constructing a tissue microarray block, and then immunohistochemistry was performed for different markers. A semi-quantitative analysis of the amount of positive tumor cells was performed by two blind and calibrated observers (Kappa>0.75). The statistical Mann-Whitney and Kruskal-Wallis tests were used to evaluate the data. The correlation between variables was investigated by the Spearman test, and the significance level set at p<0.05. We observed higher expression of Bmi-1 in tumors located in the palate (p<0.0001). In addition, poorly differentiated tumors had a greater amount of Bmi-1 positive cells (p=0.0011). Regarding the other correlations between variables, no significant associations were detected. In conclusion, poorly differentiated squamous cell carcinomas located in the palate have higher immunostaining of Bmi-1, which can characterize activation of the Epithelial-Mesenchymal Transition process in these tumors.

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“…Patients affected with HNC are frequently treated with multimodality treatment and thus can develop a wide range of acute and late side effects and long-term sequelae [3,[15][16][17][18]. The occurrence of OM in HNC patients treated with RT and/or CT is an extremely frequent finding with consistent clinical meaningfulness [7].…”

Section: Discussionmentioning

confidence: 99%

Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck cancer

et al. 2017

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Oral mucositis (OM) is a common acute side effect during radiotherapy treatments for head and neck cancer (HNC), with a potential impact on patient's compliance to therapy, quality of life (QoL) and clinical outcomes. Its timely and appropriate management is of paramount importance. Several quantitative scoring scales are available to properly assess OM and its influence on patient-reported outcomes (PROs) and QoL. We prospectively assessed OM in a cohort of HNC patients submitted to radiation using the Oral Mucositis Assessment Scale (OMAS), while its impact on PROs and QoL was evaluated employing the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer (OMWQ-HN) and the Functional Assessment of Cancer Therapy-Head and Neck Cancer (FACT-HN). Evaluation of OMAS scores highlighted a progressive increase in OM during treatment and a partial recovery after the end of radiation. These trends were correlated to PROs and QoL as evaluated with OMWQ-HN and FACT-HN questionnaires. In the present study, we provided a quantitative assessment of OM, PROs and QoL in HNC patient undergoing radiotherapy, potentially useful for future comparison.

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Parameters and outcomes in 525 patients operated on for oral squamous cell carcinoma

Cited by 38 publications

References 57 publications

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Analysis of the Epithelium-Mesenchymal Transition Process on Oral Squamous Cell Carcinomas

Prospective assessment of oral mucositis and its impact on quality of life and patient-reported outcomes during radiotherapy for head and neck cancer

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