Parameters indicative of absorption and biological effect in new lead exposure: a prospective study

Koproporphyrin [Biomonitoring Methods in German language, 1978b]

“…Nach Angaben von Schermuly und Doss [5 ] werden bei Bleivergiftungen 95% der Koproporphyrine in Form des Isomeren III ausgeschieden. Ein Anstieg der Koproporphyrinkonzentration im Urin wird ab Blutbleispiegeln von 40 µg/100 ml beobachtet [6]. Oberhalb dieses Wertes ist der Koproporphyrinspiegel im Urin der Blutbleikonzentration proportional.…”

Indices of potential lead hazard.

“…Stankovic (115) reported the following concentrations for the normal, "slight," "moderate" and "severe" categories respectively: ALAU, < 4.5, <10, >10, >20 mg/I; for CPU, <90, <180, >180 and >700 1ug/. In small children (116), the upper normal for CPU was 75 ,ug/24 hr and for adults (117,118) (19), who also studied initial exposures. Hb remained at >13 mg/100 ml and there were no clinical symptoms.…”

“…. Decreased ALAD [8-aminolevulinic acid dehydrase] activity, as measured in vitro in mature red cells in peripheral blood, is considered a 'subcritical effect' (16) though it is a highly useful indirect indicator of exposure (19,20). "…”

“…No-response (no inhibition) level, about 10 Ag Pb/100 ml; >40% inhibition in adults, [15][16][17][18][19][20] ,ug/100 ml and in chilren, 5-10 ,g/100 ml; >70% inhibition in adults, 25-30 ,g/100 ml and in children, 20-25 ,ug/100 ml.…”

“…These data are not presented. Rosen et al (24,48) determined plasma lead concentrations by flameless atomic absorption spectrometry for 165 children including: 13 newborns, 14 and 17 children, respectively, with "normal" PbB values of 20-29 or 30-39 ,ug/100 ml; [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] children in succeeding 10 pLg/100 ml PbB range groups up to 90-99 ,ug/100 ml; 10 children in the 100-136 ,ug/100 ml range; and 17 children with sickle cell disease, who had PbB concentrations of ,ug/100 ml. The plasma lead concentration for each group was between 1 and.…”