Parameters of the Lyman Model for Calculation of Normal-Tissue Complication Probability: A Systematic Literature Review

Dennstädt, Fabio; Medová, Michaela; Putora, Paul Martin; Glatzer, Markus

doi:10.1016/j.ijrobp.2022.08.039

Cited by 7 publications

(4 citation statements)

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“…However, the DVH only contains physical and noncomprehensive dose–volume metrics for tumors and adjacent organs at risk (OARs). To remedy this, the NTCP and TCP radiobiological models have been developed to assess and quantify the consequences of radiation treatments in controlling tumors and sparing normal tissues 2,3 . The NTCP parameters that link the radiotherapy outcome to a specific endpoint are derived empirically.…”

Section: Introductionmentioning

confidence: 99%

“…it is the responsibility of medical physicists, radiation oncologists, or radiobiologists to choose the appropriate NTCP parameters given patient‐specific characteristics. A study by Dennstädt et al considered the differences in NTCP parameters among different organs from different publications and the great variation result from different NTCP parameters 3 . The aim of this paper is to provide an overview of the various NTCP model parameters used for head and neck radiotherapy based on a collection of clinical data.…”

Section: Introductionmentioning

confidence: 99%

“…To remedy this, the NTCP and TCP radiobiological models have been developed to assess and quantify the consequences of radiation treatments in controlling tumors and sparing normal tissues. 2,3 The NTCP parameters that link the radiotherapy outcome to a specific endpoint are derived empirically. The accuracy of the NTCP model depends on the validity and accuracy of the assigned parameter values collected from clinical endpoint data.…”

mentioning

confidence: 99%

“…A study by Dennstädt et al considered the differences in NTCP parameters among different organs from different publications and the great variation result from different NTCP parameters. 3 The aim of this paper is to provide an overview of the various NTCP model parameters used for head and neck radiotherapy based on a collection of clinical data.…”

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confidence: 99%

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A systematic review of the normal tissue complication probability models and parameters: Head and neck cancers treated with conformal radiotherapy

Tajiki,

Joya,

Gharekhani

et al. 2023

Head & Neck

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This systematic review study aims to provide comprehensive data on different radiobiological models, parameters, and endpoints used for calculating the normal tissue complication probability (NTCP) based on clinical data from head and neck cancer patients treated with conformal radiotherapy. A systematic literature search was carried out according to the PRISMA guideline for the identification of relevant publications in six electronic databases of Embase, PubMed, Scopus, and Google Scholar to July 2022 using specific keywords in the paper's title and abstract. The initial search resulted in 1368 articles for all organs for the review article about the NTCP parameters. One hundred and seventy‐eight articles were accepted for all organs with complete parameters for the mentioned models and finally, 20 head and neck cancer articles were accepted for review. Analysis of the studies shows that the Lyman‐Kutcher‐Burman (LKB) model properly links the NTCP curve parameters to the postradiotherapy endpoints. In the LKB model for esophagus, the minimum, and maximum corresponding parameters were reported as TD50 = 2.61 Gy with grade ≥3 radiation‐induced esophagitis endpoints as the minimum TD50 and TD50 = 68 Gy as the maximum ones. nmin = 0.06, nmax = 1.04, mmin = 0.1, and mmax = 0.65, respectively. Unfortunately, there was not a wide range of published articles on other organs at risk like ear or cauda equina except Burman et al. (Fitting of normal tissue tolerance data to an analytic function. Int J Radiat Oncol Biol Phys Ther. 1991;21:123–135). Findings suggest that the validation of different radiobiological models and their corresponding parameters need to be investigated in vivo and in vitro for developing a more accurate NTCP model to be used for radiotherapy treatment planning optimization.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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