The complex characteristics of explosion load as well as its increasingly high frequency in the civil environment highlight the need to develop models representing the behavior of structures under blast load. This work presents a probabilistic study of the performance of framed reinforced concrete buildings designed according to the current Italian NTC18 and European EC8 technical standards. First, a simplified single degree of freedom model representing the structural system under blast load has been developed. Then, a probabilistic approach based on Monte Carlo simulation analysis highlighted the influence of seismic demand on the behavior of Reinforced Concrete RC buildings subjected to blast load.