Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy

Raiche-Marcoux, Gabrielle; Loiseau, Alexis; Maranda, Cloé; Poliquin, Audrée; Boisselier, Élodie

doi:10.3390/ijms232416191

Cited by 6 publications

(4 citation statements)

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“…The surface plasmon resonance effect causes an absorbance band in the electromagnetic spectrum, usually in the visible light range. Particle size and shape, coating, particle spacing, and other variables can all have an impact on the peak [ 78 , 79 , 80 , 81 ]. The fact that we observed the peak at the region 410–450 nm corresponds with the literature data for spherical nanoparticles [ 45 , 82 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

et al. 2023

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Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles. Results: The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary.

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Section: Resultsmentioning

confidence: 99%

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

et al. 2023

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“…The position of the SPR in the visible part of the spectrum also serves as a reference for the shape of the nanoparticles [ 64 , 65 , 66 , 67 , 68 ]. The wavelength of the SPR peak is in the region 410–450 nm, which is indicative of the spherical shape of the obtained nanoparticles [ 41 , 69 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…The SPR property of metallic NPs is one of the most important characteristics, which depends on the size and shape of synthesized metals [63]. The position of the SPR in the visible part of the spectrum also serves as a reference for the shape of the nanoparticles [64][65][66][67][68]. The wavelength of the SPR peak is in the region 410-450 nm, which is indicative of the spherical shape of the obtained nanoparticles [41,69,70].…”

Section: Physical Characterizations Of Galactose-assisted Drug-loaded...mentioning

confidence: 99%

Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant

Nikolova,

Milusheva,

Gledacheva

et al. 2023

Biomedicines

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Anticoagulants prevent the blood from developing the coagulation process, which is the primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known anticoagulant that is rarely employed because it totally prevents coagulation, which can be a life-threatening complication. The goal of the current study is to synthesize drug-loaded Ag NPs to slow down the coagulation process. Methods: A rapid synthesis and stabilization of silver nanoparticles as drug-delivery systems for phenindione (PID) were applied for the first time. Results: Several methods are used to determine the size of the resulting Ag NPs. Additionally, the drug-release capabilities of Ag NPs were established. Density functional theory (DFT) calculations were performed for the first time to indicate the nature of the interaction between PID and nanostructures. DFT findings supported that galactose-loaded nanostructure could be a proper delivery system for phenindione. The drug-loaded Ag NPs were characterized in vitro for their antimicrobial, cytotoxic, and anticoagulant activities, and ex vivo for spasmolytic activity. The obtained data confirmed the drug-release experiments. Drug-loaded Ag NPs showed that prothrombin time (PT, sec) and activated partial thromboplastin time (APTT, sec) are approximately 1.5 times longer than the normal values, while PID itself stopped coagulation at all. This can make the PID-loaded Ag NPs better therapeutic anticoagulants. PID was compared to PID-loaded Ag NPs in antimicrobial, spasmolytic activity, and cytotoxicity. All the experiments confirmed the drug-release results.

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“…Our study centered on the synthesis and application potential of gold and silver NPs, recognizing their versatility and significant promise, particularly within the biomedical field. AuNPs exhibit diverse diagnostics, sensor development, photo imaging, and photothermal therapy applications [ 15 , 16 ]. Their unique optical properties, finely tunable through size and shape control, underscore their versatility and excellent biocompatibility, positioning them as pivotal components in various medical technologies.…”

Section: Introductionmentioning

confidence: 99%

Harnessing barley grains for green synthesis of gold and silver nanoparticles with antibacterial potential

Singh,

Mijakovic

2024

Discover Nano

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The continuous evolution and significance of green resources-based nanomaterials have spurred the exploration of sustainable sources for nanoparticle production. Green synthesis routes offer eco-friendly methodologies, ensuring nanoparticle stability and monodispersity, enhancing their efficiency for various applications. Notably, the thick biological corona layer surrounding nanoparticles (NPs) synthesized through green routes contributes to their unique properties. Consequently, there has been a surge in the development of NPs synthesis methods utilizing medicinal plants and diverse agricultural and waste resources. This study highlights the sustainable potential of barley grains for the synthesis of gold nanoparticles (Barley-AuNPs) and silver nanoparticles (Barley-AgNPs) as an environmentally friendly alternative, followed by NPs characterizations and their application against pathogenic bacteria: Escherichia coli UTI 89 and Pseudomonas aeruginosa PAO1. The rapid synthesis of Barley-AuNPs within 20 min and Barley-AgNPs within 30 min at 90 °C underscores the efficiency of barley as a green precursor. Characterization through advanced techniques, including SEM, TEM, EDS, AFM, DLS, FT-IR, MALDI-TOF, and sp-ICPMS, reveals the 20–25 nm size for Barley-AuNPs, while Barley-AgNPs demonstrate 2–10 nm size with spherical monodispersity. A notable contribution lies in the stability of these NPs over extended periods, attributed to a thick biological corona layer. This corona layer, which enhances stability, also influences the antimicrobial activity of Barley-AgNPs, presenting an intriguing trade-off. The antimicrobial investigations highlight the significant potential of Barley-AgNPs, with distinct minimum bactericidal concentrations (MBC) against P. aeruginosa and E. coli at 8 µg/mL. Overall, this research pioneers the use of barley grains for nanoparticle synthesis and unveils these nanoparticles' unique characteristics and potential antibacterial applications, contributing to the evolving landscape of sustainable nanotechnology. Graphic Abstract

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Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy

Cited by 6 publications

References 50 publications

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

Drug-Loaded Silver Nanoparticles—A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant

Harnessing barley grains for green synthesis of gold and silver nanoparticles with antibacterial potential

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