This manuscript presents the microstructure, and mechanical analysis of 3 mm thick Al 6101 (aluminum alloy) and C11000 (Cu alloy) plates Friction Stir Welded joints with and without Silver and Zinc interlayers. The tool used to make joints is made of H 13 steel, having a shoulder with 18 mm diameter and a taper pin with 4 mm tip and 6 mm root diameter. The quality of welded joints has been inspected using tensile testing, micro-hardness tests, scanning electron microscopy, and energy dispersive X-ray analysis. Microstructural studies clari ed the ow variation of constituents with and without interlayer.Incorporation of a Silver and Zinc interlayer between the joining surface of aluminum and copper alloy decreased the generation of brittle intermetallics. The joint made with hybrid interlayers (Silver and Zinc) has the highest tensile strength with complete ductile fracture compared to the other joints tested.