Parametric study of irreversible electroporation with different needle electrodes: Electrical and thermal analysis

Nickfarjam, Abolfazl; Firoozabadi, Seyed Mohammad

doi:10.3109/02656736.2014.937775

Cited by 22 publications

(31 citation statements)

References 43 publications

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“…The clamp harboring the electrodes was also held at an angle with respect to the long axis of the nerve, in contrast to the perpendicular orientation in our study. These differences in local tissue environment and electrode orientation might increase the actual electric potential delivered to the nerves (14,15). We used ultrasound guidance during electrode insertion to avoid puncturing the nerve and to ensure that the neurovascular bundle was positioned perpendicularly at the midpoint of the paired electrodes.…”

Section: Discussionmentioning

confidence: 99%

Irreversible Electroporation of the Femoral Neurovascular Bundle: Imaging and Histologic Evaluation in a Swine Model

Wong

Hui

Chan

et al. 2015

Journal of Vascular and Interventional Radiology

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Section: Discussionmentioning

confidence: 99%

Irreversible Electroporation of the Femoral Neurovascular Bundle: Imaging and Histologic Evaluation in a Swine Model

Wong

Hui

Chan

et al. 2015

Journal of Vascular and Interventional Radiology

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“…The temperature distribution was determined by solving a modified Pennes bioheat transfer equation [24,29,40]:…”

Section: Calculation Of Temperature Distributionmentioning

confidence: 99%

“…The tissue electrical conductivity was determined using the following equation to incorporate changes due to electroporation and thermal effect [24,26,41,42]:…”

Section: Tissue Electrical Conductivitymentioning

confidence: 99%

“…Generally, a numerical study for IRE should include both electrical and thermal analyses. High-voltage electric pulses constitute the energy source used to create an ablation lesion during IRE, which can be treated as an irreversible electrical injury (EI) to tissues [24]. For electrical analysis, the electric field distribution and total energy delivered to the tissues need to be investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, thermal analysis should be considered to prevent thermal effects. A modified Pennes bioheat transfer equation was initially used to calculate the temperature distribution by electro-thermal coupling [24,29]. Subsequently, the Arrhenius equation was used to calculate the accumulated TI [30].…”

Section: Introductionmentioning

confidence: 99%

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Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Ren

Liu

Gao

et al. 2019

International Journal of Hyperthermia

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Introduction: Irreversible electroporation (IRE) combined with a catheter-based electrode during endoscopy is a potential alternative treatment method for digestive tract tumors. The aim of this study was to investigate the electrical injury (EI) and thermal injury (TI) to the digestive tract via numerical analyses and to evaluate the role and impact of electrode configurations and pulse settings on the efficacy and outcomes of IRE. Materials and methods: A finite element method was used to solve the numerical model. A digestive tract model having 4-mm-thick walls and two catheter-based electrode configuration models were constructed. The distributions of electric fields, temperature, electrical conductivity, tissue injury and limitation on the pulse number required for IRE were calculated and compared. Results: Electrode length is an important geometric parameter for electrodes in the monopolar model (MPM), while electrode spacing affects the outcomes in the bipolar model (BPM). Increasing the pulse voltage reduces the pulse number required for tissue ablation, while increasing the risk of TI. In total, there were 6 NT-IRE protocols, 12 thermal-IRE protocols and 30 TI protocols. All of the NT-IRE protocols were set in BPMs with a voltage of 0.50 kV. With increasing electrode spacing, the minimum pulse number decreased. However, thermal effects were inevitable in the MPM. Conclusions: The electrode configuration and pulse settings are adjusted to achieve NT-IRE synergistically. The BPM is more reliable for achieving NT-IRE in 4-mm-thick digestive wall. Future in vitro and in vivo studies are needed to support and validate this conclusion. ARTICLE HISTORY

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Comprehensive review on thermal aspects of nonthermal irreversible electroporation

Wijayanta

Kurata

2023

Heat Trans

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Irreversible electroporation (IRE) is an innovative cell ablation method based on the concept that the application of excessive electric pulses induces a lethal increase in the permeability of the cell membrane owing to nanoscale defects, resulting in a gentle form of necrotic cell death. Although the mechanism of cell death by IRE is primarily nonthermal, thermal effects are inevitable because electric pulses inherently generate Joule heat. The larger the applied voltage to treat a large target, the greater the Joule heating and the consequent temperature rise. Therefore, the temperature increase due to Joule heating during pulse application should be carefully controlled to minimize thermal damage. Research on IRE is an interdisciplinary endeavor incorporating health science for humanitarian relief and engineering. Therefore, this study provides a comprehensive review of the thermal aspects of IRE based on existing in vitro and in vivo experimental and numerical studies. The paper begins with an overview of IRE treatment covering the geometry and arrangement of electrodes, pulse parameters, and cell death mechanisms, followed by sections on thermal damage evaluation that summarize the significant work of experiments, analysis, and comparisons. Finally, thermal mitigation strategies, including electrode modification,

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Parametric study of irreversible electroporation with different needle electrodes: Electrical and thermal analysis

Abstract: These findings suggest that needle electrodes should not be placed within the tumour tissue if the goal is to prevent thermal damage. This method can be used as a trade-off between electric field coverage in tumour tissue and thermal damage to both tumour and normal tissue.

Cited by 22 publications

References 43 publications

Irreversible Electroporation of the Femoral Neurovascular Bundle: Imaging and Histologic Evaluation in a Swine Model

Irreversible Electroporation of the Femoral Neurovascular Bundle: Imaging and Histologic Evaluation in a Swine Model

Electrical and thermal analyses of catheter-based irreversible electroporation of digestive tract

Comprehensive review on thermal aspects of nonthermal irreversible electroporation

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