Paraneoplastic cerebellar degeneration: initial presentation in a patient with anaplastic T-cell lymphoma, associated with ichthyosiform cutaneous lesions

Rodis, Dionisis G.; Liatsos, George D.; Moulakakis, Antonios; Pirounaki, Maria; Tasidou, Anna

doi:10.1080/10428190903030858

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…47 Only a few cases of PCD associated with NHL have been reported. 17,[48][49][50] The pathological hallmark of PCD is a severe loss of Purkinje cells of the cerebellum that results in subacute pancerebellar dysfunction. The usual presentation is dizziness and vertigo that rapidly progress to severe usually symmetrical truncal and limb ataxia, with dysarthria, diplopia, and frequent down-beat nystagmus.…”

Section: Pcdmentioning

confidence: 99%

Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas

Graus

Ariño

Dalmau

2014

Blood

154

122

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Paraneoplastic neurological syndromes (PNSs) rarely associate with Hodgkin lymphoma (HL) and non-HLs (NHLs). Except for paraneoplastic cerebellar degeneration (PCD) in HL and dermato/ polymyositis in both HL and NHL, other PNSs are uncommon and have only been reported as isolated case reports or short series. There are several important differences in PNSs when occurring in association with HL and NHL compared with those associated with solid tumors. First, some PNSs such as sensory neuronopathy or Lambert-Eaton myasthenic syndrome rarely occur in lymphomas, whereas others, such as granulomatous angiitis, are only described in HL. Second, onconeural antibodies are absent in most PNSs associated with lymphomas with the exceptions of Tr (δ/notch-like epidermal growth factor-related receptor) in PCD and mGluR5 in limbic encephalitis (LE). The antigens recognized by these antibodies are not expressed in lymphoma cells, suggesting the tumor itself does not trigger the PNS. Third, unlike patients with solid tumors in patients with lymphoma, the PNSs often develops at advanced stages of the disease. Furthermore, the type and frequency of PNSs are different between HL and NHL; whereas LE and PCD occur almost exclusively in patients with HL, sensorimotor neuropathies and dermatomyositis are more frequent in NHL.

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Section: Pcdmentioning

confidence: 99%

Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas

Graus

Ariño

Dalmau

2014

Blood

154

122

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Gastric diffuse large B cell lymphoma presenting as paraneoplastic cerebellar degeneration: Case report and review of literature

Lakshmaiah

Viveka

Kumar

et al. 2013

Journal of the Egyptian National Cancer Institute

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Paraneoplastic cerebellar degeneration (PCD) is a type of paraneoplastic neurological disorder (PND) that is associated with many solid tumors, Hodgkin's lymphoma (HL) and very rarely with non-Hodgkin's lymphoma (NHL). We report a case of PCD associated with gastric diffuse large B-cell lymphoma (DLBCL) in a patient who presented with acute onset of giddiness and double vision and had complete remission of the gastric lesion and marked improvement of cerebellar syndrome with rituximab-based combination chemotherapy. A brief review of the literature is also presented.

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