Paraneoplastic frontal lobe disorder and ataxia in renal cell carcinoma

Hagel, Christian; Stavrou, D.; Hansen, Hans Christian

doi:10.1111/j.1365-2990.2004.00609.x

Cited by 13 publications

(7 citation statements)

References 11 publications

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“…The presentation of renal cell carcinoma-associated paraneoplastic neurological syndrome has been described as a rare condition. Another manifestations besides cerebellar degeneration have been reported, such as opsoclonus-myoclonus syndrome and frontal lobe disorder [6, 7]. .In contrast to other paraneoplastic syndromes, such as lung, breast or ovarian cancer, in which specific antineuronal antibodies have been identified, no antineuronal antibodies have been described in renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“….In contrast to other paraneoplastic syndromes, such as lung, breast or ovarian cancer, in which specific antineuronal antibodies have been identified, no antineuronal antibodies have been described in renal cell carcinoma. However, there is strong evidence of a causative association between neurological lesion and an underlying immune-mediated tumor process [7].…”

Section: Discussionmentioning

confidence: 99%

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Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

et al. 2019

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Background Paraneoplastic cerebellar degeneration is usually associated with gynecological and breast cancer, lung cancer, and Hodgkin’s lymphoma. Renal cell carcinoma has rarely been described as an underlying malignancy in these cases. Case presentation We report the case of a 75 year-old woman who develop cerebellar ataxia following a respiratory viral infection. During investigation, around 1 year afterward, she noticed constitutional symptoms suggestive of malignancy. Renal carcinoma was found and the hypothesis of paraneoplastic cerebellar degeneration was considered. Conclusions As no specific antineuronal antibodies have been described in the setting of renal cell carcinoma, paraneoplastic cerebellar degeneration should be considered when the tumor is detected and other causes are excluded. Immunotherapy should be prescribed as soon as possible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

et al. 2019

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“…En lo referente a la afectación neurológica, los síndromes paraneoplásicos asociados al carcinoma renal pueden incluir manifestaciones muy diversas, que incluyen tanto al sistema nervioso central como al periférico. Han sido descritas polineuroptías sensitivas y motoras, incluso con parálisis bilateral del nervio frénico, esclerosis lateral amiotrófica, degeneración cerebelosa subaguda, síndrome del lóbulo frontal, cuadros extrapiramidales de tipo coréico y balístico, y síndrome de opsoclonus-mioclonus [10][11][12][13][14][15][16][17][18][19] .…”

Section: Discussionunclassified

Carcinoma renal que debuta como cuadro neurológico paraneoplásico

Hens

Camacho

Maestre

et al. 2008

Actas Urológicas Españolas

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“…En lo referente a la afectación neurológica, los sín-dromes paraneoplásicos asociados al carcinoma renal pueden incluir manifestaciones muy diversas, que incluyen tanto al sistema nervioso central como al periférico. Han sido descritas polineuroptías sensitivas y motoras, incluso con parálisis bilateral del nervio frénico, esclerosis lateral amiotrófica, degeneración cerebelosa subaguda, síndrome del lóbulo frontal, cuadros extrapiramidales de tipo coréico y balístico, y síndrome de opsoclonus-mioclonus [10][11][12][13][14][15][16][17][18][19] .…”

Section: Discussionunclassified

Carcinoma renal que debuta como cuadro neurológico paraneoplásico

Hens¹,

Camacho²,

Maestre³

et al. 2008

Actas Urol Esp

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RESUMENCARCINOMA RENAL QUE DEBUTA COMO CUADRO NEUROLÓGICO PARANEOPLÁSICO Introducción: Los procesos tumorales pueden de manera ocasional mostrar su primera manifestación con una sintomatología neurológica, no originada por metástasis, sino del denominado tipo paraneoplási-co, que puede aparecer incluso años antes de los síntomas habituales del tumor. Este tipo de manifestaciones iniciales pueden ser la clave del descubrimiento de una neoplasia oculta.Métodos: Presentamos el caso de un varón de 66 años afecto de un carcinoma renal, cuya manifestación inicial consistió únicamente en un cuadro neurológico progresivo de tipo cerebeloso paraneoplásico, aparecido 6 años antes de la primera sintomatología urológica.Conclusiones: La aparición de una sintomatología neurológica cerebelosa progresiva puede ser la única y primera manifestación de un carcinoma renal, incluso años antes de las primeras manifestaciones uroló-gicas. Debe sospecharse la existencia de una neoplasia oculta en los pacientes con esta sintomatología. ABSTRACTRENAL CELL CARCINOMA PRESENTING AS PARANEOPLASTIC NEUROLOGICAL DYSFUNCTION Introduction: Malignant tumors sometimes initiate as paraneoplastic syndromes even years before the most common symptoms appear. These first manifestations could be the key for the diagnosis of "occult" malignancy.Methods: We report the case of a 66 year old man with a renal cell carcinoma. The first symptom was a paraneoplastic cerebellar degeneration appeared 6 years before the first urologic manifestations.Conclusions: A progressive cerebellar syndrome could be the first manifestation of a renal cell carcinoma, even years before the first urologic symptoms. We must suspect an occult neoplasia in such patients.

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Paraneoplastic frontal lobe disorder and ataxia in renal cell carcinoma

Cited by 13 publications

References 11 publications

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

Carcinoma renal que debuta como cuadro neurológico paraneoplásico

Carcinoma renal que debuta como cuadro neurológico paraneoplásico

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