Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent

Ismail, Ismail Ibrahim; John, John K.; Ibrahim, M. Kassih; Al-Hashel, Jasem Yousef

doi:10.1159/000505232

Cited by 11 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anti-CRMP5-associated paraneoplastic encephalitis is rare. Most cases are associated with SCLC, occurring in 5% of patients 8. Although the patient presented pleocytosis, he had no symptoms suggestive of encephalitis.…”

Section: Discussionmentioning

confidence: 85%

Paraneoplastic Lambert-Eaton myasthenic syndrome: a diagnostic challenge

et al. 2023

View full text Add to dashboard Cite

Lambert-Eaton myasthenic syndrome (LEMS) is a rare neuromuscular junction disorder. Underlying small cell lung cancer is found in more than half of patients. Proximal muscle weakness, autonomic features and areflexia are typical manifestations. However, LEMS is often misdiagnosed. We report a rare case of paraneoplastic LEMS, identified amid admission due to a different diagnosis. Our patient was initially admitted due to aspiration pneumonia. Further investigation revealed clinical and electrophysiological manifestations of LEMS. High clinical suspicion and early diagnostic workup were paramount in the patient outcome. Nevertheless, paraneoplastic aetiology was difficult to confirm and revealed itself a difficult challenge. Clinical awareness is crucial to diagnose LEMS and urge cancer screening and early treatment.

show abstract

Section: Discussionmentioning

confidence: 85%

Paraneoplastic Lambert-Eaton myasthenic syndrome: a diagnostic challenge

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Presently, even though the anti-CRMP 5 antibodies are rare among the intracellular antibody spectrum, it has a documented oncological association of 75% toward SCLC and 15% toward thymoma, with patients between 30 and 50 years old, being equally found in men and women. However, a 2020 study has reported the correlation of the autoantibody with thymoma 19 . In a clinical perspective based on the largest conducted study regarding anti-CRMP 5 antibody detection, it was reported that the primary psychiatric manifestation was nonspecified personality change (11%), followed by depression (9%) and psychosis (4%) 32 …”

Section: Resultsmentioning

confidence: 99%

A scoping review on paraneoplastic autoimmune limbic encephalitis (PALE) psychiatric manifestations

Fernandes

Marques

2020

CNS Spectr.

View full text Add to dashboard Cite

The term limbic encephalitis has been used with an oncological precedent for over 50 years and, since then, has been applied in relation to multiple antibodies found in its etiological process. Over the last decade, the psychiatric community has brought paraneoplastic autoimmune limbic encephalitis (PALE) to a new light, scattering the once known relationships between said screened antibodies responsible for causing limbic encephalitis. Due to the fact that some individuals with this condition have a psychiatric syndrome as an initial manifestation, the aim of this updated scoping review is to reestablish a causal relationship between the onconeuronal autoantibodies, both intracellular and extracellular, possible underlying malignancies and subsequent neuropsychiatric syndrome. In pair with it, there is the idea of sketching a cleaner thorough picture of what poses as psychiatric symptoms as well as possible therapeutics. Even though the always evolving epistemology of the neurosciences achieved a significant unveiling of what includes PALE in its relevant pathological subgroups, the amount of gray literature still is much superior, appealing to a further research with more randomized controlled trials, with larger populations, so that the results corroborate the small amount of data that already exist and posteriorly be applied in the general population.

show abstract

“…The CRMP5 antibody is an intracellular antibody that is almost always paraneoplastic and most commonly seen in SCLC (about 75% of cases), again not with other types of lung cancer [ 14 , 15 ]. Clinically, CRMP5 is frequently associated with painful peripheral neuropathies and cerebellar ataxia.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Two Paraneoplastic Neurological Syndromes in a Patient With Lung Cancer

Pia¹,

Looi²,

Stone³

et al. 2022

Cureus

View full text Add to dashboard Cite

Paraneoplastic immune-mediated disorders have been well described in the literature. However, it is still relatively rare. The incidence has increased over the past decade due largely to the discovery of more autoantibodies. With a better understanding of the pathophysiology of different autoantibodies and clinical phenotypes, we are often able to diagnose clinically some specific paraneoplastic autoimmune neurological syndromes. We may also predict the response to treatment based on the autoantibody class. We are presenting a very unusual case of two completely different paraneoplastic syndromes with two different autoantibodies, gamma-aminobutyric acid-B (GABA B ) and collapsin response mediator protein 5 (CRMP5), in a patient with underlying small-cell lung cancer. We will discuss the differences in the two antibody syndromes, their significance, and their management.

show abstract

Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent

Cited by 11 publications

References 14 publications

Paraneoplastic Lambert-Eaton myasthenic syndrome: a diagnostic challenge

Paraneoplastic Lambert-Eaton myasthenic syndrome: a diagnostic challenge

A scoping review on paraneoplastic autoimmune limbic encephalitis (PALE) psychiatric manifestations

An Unusual Case of Two Paraneoplastic Neurological Syndromes in a Patient With Lung Cancer

Contact Info

Product

Resources

About