Paraneoplastic scleroderma in Kaposi's sarcoma: Report of two cases

Ali, Sara Oulad; Belcadi, Jihane; Znati, Kaoutar; Meziane, M.; Ismaïli, Nadia; Benzekri, Laïla; Senouci, Karima

doi:10.1002/ski2.189

Cited by 1 publication

(2 citation statements)

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“…Additionally, paraneoplastic scleroderma has also been reported in cases of Kaposi sarcoma. Here, the pathogenesis could be mediated by profibrotic TGF-beta and VEGF hyperproduction by fibroblasts infected with HHV8 [ 48 ].…”

Section: Morpheamentioning

confidence: 99%

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Skin Hypopigmentation in Hematology Disorders

Mazzetto,

Miceli,

Sernicola

et al. 2024

Hematology Reports

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Hypopigmentation disorders pose significant diagnostic challenges in dermatology, sometimes reflecting underlying hematological conditions. This review explores the clinical presentations related to hypopigmentation in hematological disorders, focusing on vitiligo, morphea, and syndromic albinism. Vitiligo, an autoimmune disorder targeting melanocytes, involves interactions between genetic polymorphisms and immune responses, particularly regarding CD8+ T cells and IFN-γ. Drug-induced vitiligo, notably by immune checkpoint inhibitors and small-molecule targeted anticancer therapies, underscores the importance of immune dysregulation. Morphea, an inflammatory skin disorder, may signal hematological involvement, as seen in deep morphea and post-radiotherapy lesions. Syndromic albinism, linked to various genetic mutations affecting melanin production, often presents with hematologic abnormalities. Treatment approaches focus on targeting the immune pathways specific to the condition, and when that is not possible, managing symptoms. Understanding these dermatological manifestations is crucial for the timely diagnosis and management of hematological disorders.

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Section: Morpheamentioning

confidence: 99%

“…Patients affected by a syndromic form of albinism are vulnerable to pyogenic bacterial infections, especially in the respiratory tract and the skin, due to impaired neutrophil number and function [ 48 ].…”

Section: Syndromic Albinismmentioning

confidence: 99%