“…Netrin-1 is expressed by myelinating oligodendrocytes and locally enriched at central nervous system (CNS) paranodes (Bull et al, 2014;Jarjour et al, 2008;Manitt et al, 2001;Manitt, Thompson, & Kennedy, 2004). Selective deletion of the netrin-1 receptors deleted in colorectal carcinoma (DCC) or UNCoordinated-5 homologue B from oligodendrocytes severely disrupts paranodal junctions (Bull et al, 2014;de Faria et al, 2020). Emerging evidence indicates that netrins influence the formation of epithelial cell-cell junctions (Beamish, Hinck, & Kennedy, 2018), and direct the local recruitment of synaptic proteins and formation of synaptic specializations in neurons (Colon-Ramos, Margeta, & Shen, 2007;Goldman et al, 2013;Lai Wing Sun, Correia, & Kennedy, 2011;Poon, Klassen, & Shen, 2008).…”