Paraoxonasa, ¿algo más que una enzima?

Canales, Amaia; Sánchez‐Muniz, Francisco J.

doi:10.1016/s0025-7753(03)74011-1

Cited by 66 publications

(12 citation statements)

References 96 publications

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“…PON1 has been suggested as the factor largely responsible for the antioxidant role of HDL (8). PON1 is an enzyme with three activities: paraoxonase, arylesterase and diazoxonase (32), and its activity is inversely related to the risk of CAD (33). In our study, serum PON1 activities in patients with CAD were found to be significantly lower than those in the healthy control group.…”

Section: Group N Tc/hdl-c Ldl-c/hdl-c Ox-ldl/ldl-ccontrasting

confidence: 37%

Paraoxonase Activity and Oxidized LDL Levels as Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Ayoglu¹,

Ekmekçi²,

Ekmekçi³

et al. 2013

Istanbul Med J

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Bu çalışmada koroner arter hastalarında damar tıkanıklığının şiddetine bağlı olarak serum Okside LDL (Ox-LDL) konsantrasyonu; son zamanlarda kardiyovasküler risk faktör olarak tanımlanan Paraoksonaz 1 (PON1) aktivitesi ve tiobarbitürik asit reaktif substansları (TBARS) düzeyleri arasındaki olası ilişki araştırıldı. Yöntemler: Okside LDL, Apolipoprotein AI (Apo AI), TBARS düzeyleri, PON1 aktivitesi lipid profili (Total Kolesterol (TK), Trigliserid (TG), LDL Kolesterol (LDL-K), HDL Kolesterol (HDL-K), VLDL Kolesterol (VLDL-K) düzeyleri 42 koroner arter hastası ve 17 sağlıklı bireyde belirlendi. Hasta grubu anjiografi sonuçlarına göre tek damar (n:13), iki damar (n:15) ve üç damar (n:14) olarak 3 alt gruba bölündü. PONI aktivitesi ve TBARS düzeyleri spektrofotometrik, Ox-LDL düzeyleri Eliza, Apo-AI immunoturbidimetrik, TK, TG ve HDL-K düzeyleri ise enzimatik yöntemlerle tayin edildi. Bulgular: Çalışmamızda damar tıkanıklık derecesi arttıkça PON1 aktivitesinin azaldığı gözlendi (r:-0,537, p<0,01). Tek damar, iki damar, üç damar ve total hasta grubunda Ox-LDL düzeyleri kontrol grubuna göre istatistiksel olarak yüksek bulundu (p<0,01). TBARS düzeyleri tek, iki ve üç damar tıkanıklığı bulunan hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek bulundu (p<0,01). Tek, iki ve üç damar tıkanıklığı bulunan bireylerde Apo AI düzeyleri ise kontrol grubundan düşük bulundu (p<0,01). Sonuç: Sonuçlarınmız düşük PON1aktivitesi, yüksek Ox-LDLve TBARS düzeyleri, düşük Apo AI düzeylerinin koroner arter hastalığının patogenezinde önemli rol oynayabileceğini göstermektedir.

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Section: Group N Tc/hdl-c Ldl-c/hdl-c Ox-ldl/ldl-ccontrasting

confidence: 37%

Paraoxonase Activity and Oxidized LDL Levels as Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Ayoglu¹,

Ekmekçi²,

Ekmekçi³

et al. 2013

Istanbul Med J

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“…30,31 Decreased PON1 activity was observed in patients with different diseases, including coronary artery disease, hypercholesterolemia, type 2 diabetes or iron-deficiency anemia. 32–34 Decreased serum PON1 activities in different types of cancers (including lung, pancreatic, gastric, esophageal and prostate) have also been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Total Oxidant Status, Total Antioxidant Status, and Paraoxonase and Arylesterase Activities during Laparoscopic Cholecystectomy

Köksal

Kurban

2010

Clinics

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INTRODUCTION:Laparoscopic cholecystectomy is the gold standard for the treatment of gallstone disease; however, adverse hemodynamic changes induced by increased intraabdominal pressure due to pneumoperitoneum are known to occur. Herein, we investigated the effects of pneumoperitoneum on oxidative stress markers, including paraoxonase, arylesterase, total oxidant status, and total antioxidant status, during laparoscopic cholecystectomy.PATIENTS AND METHODS:Patients that underwent a laparoscopic cholecystectomy were classified as Group I, whereas patients that underwent surgical procedures for an abdominal wall hernia under general anesthesia were classified as Group II. Blood samples were obtained during the preoperative period, the perioperative period, and 24 hours after surgery (postoperative day 1). Leukocyte counts, neutrophil rates, paraoxonase activities, arylesterase activities, and total oxidant and antioxidant status levels were measured.RESULTS:The differences in leukocyte counts and neutrophil rates were not significant between the two groups. In Group I, no significant differences in the total oxidant and antioxidant status levels were identified; however, paraoxonase and arylesterase levels were lower on postoperative day 1. No significant changes were observed in the total oxidant status, total antioxidant status, and paraoxonase or arylesterase activities in Group II. The perioperative total antioxidant status and arylesterase level were higher in Group I in comparison to Group II.CONCLUSION:Paraoxonase and arylesterase levels are useful markers in the evaluation of oxidative stress caused by intraabdominal pressure due to pneumoperitoneum.

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“…PON1 is an antioxidant enzyme related to high-density lipoprotein (HDL) regulation in the blood and is a very important ester hydrolase that protects lipoproteins from oxidation [13].…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase 1 (PON1) gene Q192R polymorphism in patients with vitiligo

Akçılar¹,

Namdar²

2022

J Surg Med

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Background/Aim: Vitiligo is a prevalent inflammatory illness that can affect the skin and mucosal surfaces and is characterized by patchy loss of skin pigmentation. Paraoxonase1 (PON1) is an esterase enzyme with antioxidant properties that binds to high-density lipoproteins. We examined whether the PON1 gene Q192R polymorphism is a risk factor for vitiligo among Turkish people. Methods: The study included 70 controls and 60 vitiligo cases. Polymerase chain reaction and the restriction fragment length polymorphism technique were used to genotype the PON1 gene Q192R polymorphism. Results: PON1 gene Q192R genotype distribution was 66.7% QQ, 33.3% QR, and 0% RR in the vitiligo and 81.4% QQ, 18.6% QR, and 0% RR in the control (P = 0.05). When vitiligo patients were compared with controls, the prevalence of the PON1 QR genotype was substantially higher and was linked to a 2.19-fold greater risk of developing vitiligo (odds ratio: 2.19, 95% confidence interval (CI): 0.97–4.91). Conclusion: These findings imply that Q192R polymorphisms in the PON-1 gene may be linked to vitiligo in the Turkish population. The PON1 QR genotype may be a major genetic risk factor for vitiligo susceptibility and progression. Further studies with larger populations should more thoroughly clarify the association.

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Paraoxonasa, ¿algo más que una enzima?

Cited by 66 publications

References 96 publications

Paraoxonase Activity and Oxidized LDL Levels as Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Paraoxonase Activity and Oxidized LDL Levels as Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Total Oxidant Status, Total Antioxidant Status, and Paraoxonase and Arylesterase Activities during Laparoscopic Cholecystectomy

Paraoxonase 1 (PON1) gene Q192R polymorphism in patients with vitiligo

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