Parasites and tissue microenvironment

Helmby, Helena; Hafalla, Julius Clemence R.

doi:10.1111/pim.12810

Parasite Immunology

2021

DOI: 10.1111/pim.12810

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Parasites and tissue microenvironment

Helena Helmby

Julius Clemence R. Hafalla

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2022

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Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice

Park

et al. 2022

Korean J Parasitol

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Vincristine (VCR) is a chemotherapeutic agent widely used in treatment of malignancies. However, VCR has a limitation in use since it commonly causes a painful neuropathy (VCR-induced peripheral neuropathy, VIPN). Inflammatory cytokines secreted by immune cells such as macrophages can exacerbate allodynia and hyperalgesia, because inhibiting the inflammatory response is a treatment target for VIPN. In this study, we investigated whether Trichinella spiralis, a widely studied helminth for its immunomodulatory abilities, can alleviate VCR-induced allodynia. Von Frey test showed that T. spiralis infection improved mechanical allodynia at 10 days after VCR injection. We further observed whether the difference was due to mitigated axon degeneration, but no significant difference between the groups in axonal degeneration in sciatic nerves and intra-epidermal nerve fibers was found. Conversely, we observed that number of infiltrated macrophages was decreased in the sciatic nerves of the T. spiralis infected mice. Moreover, treatment of T. spiralis excretory-secretory products caused peritoneal macrophages to secrete decreased level of IL-1β. This study suggests that T. spiralis can relieve VCR-induced mechanical allodynia by suppressing neuroinflammation and that application of controllable degree of helminth may prove beneficial for VIPN treatment.

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Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice

Park

et al. 2022

Korean J Parasitol

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show abstract

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Parasites and tissue microenvironment

Cited by 1 publication

References 6 publications

Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice

Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice

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