Paraspinal Extramedullary Hematopoiesis Diagnosed Using Tc-99m Sulfur Colloid

Singh, Sukhdev; Gunatunga, Ishan; Bartley, Lee; Facey, P.; Rees, John H.; Fielding, Patrick

doi:10.1097/rlu.0b013e318187ee4d

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…99m Tc-colloid scintigraphic imaging can be used to confirm the presence of bone marrow elements in a mass suspicious for extramedullary haematopoiesis, and this may be able to eliminate the need for biopsy. 9 This may be of particular use in anatomical locations that are associated with a high risk of biopsy 10 ; however, there are reports of false-negative 99m Tc-colloid examinations for extramedullary haematopoiesis. 11 EMH has been illustrated to be hypermetabolic on combined 2-[ 18 F]-fluoro-2-deoxy-D-glucose ( 18 F-FDG) positron-emission tomography (PET) and computed tomography (CT) 12 (Fig.…”

Section: Central Nervous System (Cns) Manifestationsmentioning

confidence: 97%

Extramedullary haematopoiesis: radiological imaging features

et al. 2016

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Section: Central Nervous System (Cns) Manifestationsmentioning

confidence: 97%

Extramedullary haematopoiesis: radiological imaging features

et al. 2016

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“…At FDG PET/CT, extramedullary hematopoiesis shows mild to moderate uptake, a characteristic that may help to distinguish it from most types of lymphoma, which demonstrate avid uptake of FDG. If extramedullary hematopoiesis is clinically suspected, scintigraphy with 99m Tc sulfur colloid is the imaging modality of choice to confirm the diagnosis because this technique shows uptake of the radiopharmaceutical in areas that contain bone marrow elements wherever they are located (52).…”

Section: Anemias Extramedullary Hematopoiesismentioning

confidence: 99%

Imaging Manifestations of Hematologic Diseases with Renal and Perinephric Involvement

Purysko¹,

Westphalen²,

Remer³

et al. 2016

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The kidneys and perinephric tissues can be affected by a variety of hematologic disorders, which usually occur in the setting of multisystem involvement. In many of these disorders, imaging is used to evaluate the extent of disease, guide biopsy, and/or monitor disease activity and patient response to therapy. Lymphoma, leukemia, and multiple myeloma commonly manifest as multiple parenchymal or perinephric lesions. Erdheim-Chester disease and Rosai-Dorfman disease, rare forms of multisystemic histiocytosis, are often identified as perinephric and periureteral masses. Renal abnormalities depicted at imaging in patients with sickle cell disease include renal enlargement, papillary necrosis, and renal medullary carcinoma. Sickle cell disease, along with other causes of intravascular hemolysis, can also lead to hemosiderosis of the renal cortex. Thrombosis of renal veins is sometimes seen in patients with coagulation disorders but more often occurs in association with certain malignancies and nephrotic syndrome. Immunoglobulin G4-related sclerosing disease is another multisystem process that often produces focal renal lesions, seen along with involvement of more characteristic organs such as the pancreas. Perinephric lesions with calcifications should raise the possibility of secondary amyloidosis, especially in patients with a history of lymphoma and multiple myeloma. Although the imaging patterns of renal and perinephric involvement are usually not specific for a single entity, and the same entity can manifest with different or overlapping patterns, familiarity with these patterns and key clinical and histopathologic features may help to narrow the differential diagnosis and determine the next step of care. (©)RSNA, 2016.

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“…110 The lesion is homogeneously hyperintense on T1WI, is hypointense on T2WI, and does not enhance. 114 Primary tumors of the dura, such as fibromas, fibromatosis, and sarcomas, are rare, 30 but given their extradural location, they may cause spinal cord compression. There is no enhancement of this ossified ligament ( Figure 28).…”

Section: Imaging Differential Diagnosismentioning

confidence: 99%