Parasympathetic evaluation for procedural pain assessment in neonatology

Carnicero, Luis Bachiller; Rodríguez, Miguel Antoñón; López, Aída de la Huerga; Ramos, Silvia Martín; Luengo, Félix Morales; Urueña, Sara Isabel Marín; Carbonero, Sonia Caserío

doi:10.1016/j.anpede.2022.08.013

Cited by 1 publication

(1 citation statement)

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“…Decreases in NIPE index indicate pain, whilst increases indicate improved comfort. Several studies have found that the (instant) NIPE index decreases during painful procedures and is inversely correlated with pain scores in neonates ( 40 – 44 ). However, other studies found no correlation with pain scores ( 45 , 46 ).…”

Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

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Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.

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