Parathyroid Chief Cell Adenoma Associated with Massive Chronic Parathyroiditis in a Woman with Hyperparathyroidism

Kovács, Kálmán; Bell, C. David; Juco, Jonathan; Rotondo, Fabio; Anderson, Jennifer

doi:10.1007/s12022-007-0001-0

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…Parathyroid adenoma with prominent lymphocytic infiltrate is a rare condition. Including the present case, 12 patients have been reported (Table 1) [1][2][3][4][5][6]. The median age was 58 years old (range, 29-74) with slight female predominance (male:female = 1:1.4).…”

Section: Discussionmentioning

confidence: 99%

“…The median age was 58 years old (range, 29-74) with slight female predominance (male:female = 1:1.4). Some patients (n = 4) suffered from renal colic [1], hypertension [1], duodenal ulcer [3], or osteopenia [4], which were probably associated with hyperparathyroidism [7]. Otherwise, patients were asymptomatic (n = 8).…”

Section: Discussionmentioning

confidence: 99%

“…Most patients (n = 11) had no history of autoimmune disease, except for one who had ten years of psoriasis [1]. Four patients had concomitant thyroid diseases, including nodular goiter (n = 3) [2,4] or PTC (n = 1, present). Two patients had received chemotherapy for breast cancer before diagnosis [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Four patients had concomitant thyroid diseases, including nodular goiter (n = 3) [2,4] or PTC (n = 1, present). Two patients had received chemotherapy for breast cancer before diagnosis [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…PARATHYROID ADENOMA with prominent lymphocytic infiltrate is a rare disease, characterized by prominent lymphocytic infiltration in the adenomatous parathyroid gland, which has been reported in 11 patients [1][2][3][4][5][6]. Because of its rarity, clinicopathological and immunohistochemical (IHC) characteristics of the tumor are largely unrevealed.…”

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confidence: 99%

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Parathyroid adenoma with prominent lymphocytic infiltrate having histological features highly suggestive of IgG4-related disease: a case report and literature review

et al. 2019

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Parathyroid adenoma with prominent lymphocytic infiltrate is a rare disease. Until now, 11 patients have been reported. Herein, we report a 57-year-old man who had a neck mass that was incidentally found. Aspiration cytology and subsequent needle biopsy of the tumor were performed and suggested papillary thyroid carcinoma. From the resected specimen, however, the patient was finally diagnosed with parathyroid adenoma with prominent lymphocytic infiltrate, characterized by hyperplastic parathyroid cells with nuclear atypia within fibrotic stroma along with numerous lymphocytes forming germinal centers. Some eosinophils and plasma cells were also observed with some histological features highly suggestive of IgG4-related disease (IgG4-RD), including increased IgG4-positive plasma cells and IgG4/IgG-positive plasma cell ratio, storiform-type fibrosis, and obliterative phlebitis. It turned out that microfollicular or trabecular architecture and cellular atypia with high expression of HBME-1 observed in the aspiration cytology and needle biopsy had been misinterpreted as a thyroid malignancy. This is the first report describing microscopic features of aspiration cytology and needle biopsy of parathyroid adenoma with prominent lymphocytic infiltrate, warning that it can mimic papillary thyroid carcinoma in biopsy specimens. Furthermore, the IgG4-RD-like features of the present case and previous reports imply that parathyroid adenoma with prominent lymphocytic infiltrate may be a type of IgG4-RD.

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