Parathyroid gland management using optical technologies during thyroidectomy or parathyroidectomy: A systematic review

Abbaci, Muriel; Leeuw, Frédéric De; Breuskin, Ingrid; Casiraghi, Odile; Lakhdar, Aïcha Ben; Ghanem, Wahib; Laplace‐Builhé, Corinne; Hartl, Dana M.

doi:10.1016/j.oraloncology.2018.11.011

Cited by 60 publications

(63 citation statements)

References 69 publications

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“…PGs detection has been significantly improved in 2017 by a novel method presented in a study performed by Kim et al -dynamic optical contrast imaging (DOCI) [66]. In this method, tissues are illuminated by LEDs with different wavelengths and fluorescence decay information from endogenous fluorophores is used to obtain pixel values and create color diagrams [117]. In the ex vivo study, the 127 specimens were examined by macroscopic characteristics, DOCI maps, and histopathological images.…”

Section: Dynamic Optical Contrast Imagingmentioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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Accurate pre-operative determination of parathyroid glands localization is critical in the selection of minimally invasive parathyroidectomy as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Its importance cannot be overemphasized as it helps to minimize the harmful side effects associated with damage to the parathyroid glands such as in hypocalcemia, severe hemorrhage or recurrent laryngeal nerve dysfunction. Preoperative and intraoperative methods decrease the incidence of mistakenly injuring the parathyroid glands and allow for the timely diagnosis of various abnormalities, including parathyroid adenomas. This article reviews 139 studies conducted between 1970 and 2020 (49 years). Studies that were reviewed focused on several techniques including application of carbon nanoparticles, carbon nanoparticles with technetium sestamibi (99m Tc-MIBI), Raman spectroscopy, near-infrared autofluorescence, dynamic optical contrast imaging, laser speckle contrast imaging, shear wave elastography, and indocyanine green to test their potential in providing proper parathyroid glands’ localization. Apart from reviewing the aforementioned techniques, this study focused on the applications that helped in the detection of parathyroid adenomas. Results suggest that applying all the reviewed techniques significantly improves the possibility of providing proper localization of parathyroid glands, and the application of indocyanine green has proven to be the ‘ideal’ approach for the diagnosis of parathyroid adenomas.

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Section: Dynamic Optical Contrast Imagingmentioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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“…Since the publication of this discovery, many studies have reported excellent parathyroid detection rates, as described by McWade et al in 2014 [16][17][18], with a specificity of more than 80% [19].…”

Section: Discussionmentioning

confidence: 90%

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Demarchi

Karenovicŝ

Bédat

et al. 2020

JCM

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Fluorescence imaging is a well-known method for both the in vivo and in vitro identification of specific cells or tissues. This imaging tool is gaining importance in the intraoperative detection and preservation of parathyroid glands during endocrine surgery owing to the intrinsic properties of parathyroid tissue. The aim of this paper is to provide an overview of the basics of the technology, its history, and the recent surgical intraoperative applications of near-infrared imaging methods. Moreover, a literature review of the utilization of fluorescence devices in thyroid surgery suggests that the use of near-infrared imaging seems to be beneficial in reducing postoperative hypoparathyroidism, which is one of the most frequent complications of thyroid surgery.

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“…Intraoperative identification of the parathyroid glands (PG) is a major concern either during parathyroidectomy (PTX) or when performing total thyroidectomy (TT) (1). Intraoperatively, the identification of PGs can be performed by two invasive alternatives: i) the frozen section method or ii) the "float or sink" technique.…”

Section: Angiography For the Identification Of The Parathyroid Glandsmentioning

confidence: 99%

“…The current identification method is usually based on visual inspection and palpation by the surgeon with careful preservation of the PG blood supply, depending greatly on the surgeon's experience (1).…”

Section: Angiography For the Identification Of The Parathyroid Glandsmentioning

confidence: 99%

Intraoperative Indocyanine Green (ICG) Angiography for the Identification of the Parathyroid Glands: Current Evidence and Future Perspectives

Spartalis¹,

Ntokos²,

Γεωργίου³

et al. 2019

In Vivo

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Background/Aim: Recently, indocyanine green (ICG) fluorescence imaging has been used for the identification of the parathyroid glands (PG) during thyroid and parathyroid surgery. However, an overall consensus on the optimal technique, the dosage, the timing of the ICG administration and finally its interpretation and clinical usefulness is still lacking evidence. The aim of this review is to investigate the use of ICG angiography during thyroidectomy and/or parathyroidectomy for identification as well as for the perfusion integrity of the parathyroid glands. Materials and Methods: The PubMed database was systematically searched for publications regarding intraoperative ICG imaging in patients that undergo thyroidectomy or parathyroidectomy. Results: Eighteen publications reporting on 612 patients, namely 71 parathyroidectomy and 541 thyroidectomy patients met the inclusion criteria. Eleven publications reported the use of ICG 23 This article is freely accessible online.

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Parathyroid gland management using optical technologies during thyroidectomy or parathyroidectomy: A systematic review

Cited by 60 publications

References 69 publications

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Intraoperative Indocyanine Green (ICG) Angiography for the Identification of the Parathyroid Glands: Current Evidence and Future Perspectives

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