Parathyroid Tumor Microenvironment

Verdelli, Chiara; Vaira, Valentina; Corbetta, Sabrina

doi:10.1007/978-3-030-36214-0_3

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…PTH levels are associated with the degree of renal impairment in PHPT [ 132 ], and PTX prevents further kidney impairment [ 133 ]. CKD and related complications are seen also in other forms of hyperparathyroidism (e.g., multiple endocrine neoplasia type 1 (MEN1), type 2A (MEN2A), and type 4 (MEN4), parathyroid carcinoma, and gestational hyperparathyroidism) [ 102 , 134 , 135 , 136 ].…”

Section: Evidence For a Role Of Pth In Conditions Of Abnormal Pth mentioning

confidence: 99%

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Lombardi

Ziemann²,

Banfi

et al. 2020

IJMS

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Exercise perturbs homeostasis, alters the levels of circulating mediators and hormones, and increases the demand by skeletal muscles and other vital organs for energy substrates. Exercise also affects bone and mineral metabolism, particularly calcium and phosphate, both of which are essential for muscle contraction, neuromuscular signaling, biosynthesis of adenosine triphosphate (ATP), and other energy substrates. Parathyroid hormone (PTH) is involved in the regulation of calcium and phosphate homeostasis. Understanding the effects of exercise on PTH secretion is fundamental for appreciating how the body adapts to exercise. Altered PTH metabolism underlies hyperparathyroidism and hypoparathyroidism, the complications of which affect the organs involved in calcium and phosphorous metabolism (bone and kidney) and other body systems as well. Exercise affects PTH expression and secretion by altering the circulating levels of calcium and phosphate. In turn, PTH responds directly to exercise and exercise-induced myokines. Here, we review the main concepts of the regulation of PTH expression and secretion under physiological conditions, in acute and chronic exercise, and in relation to PTH-related disorders.

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Section: Evidence For a Role Of Pth In Conditions Of Abnormal Pth mentioning

confidence: 99%

Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism

Lombardi

Ziemann²,

Banfi

et al. 2020

IJMS

Self Cite

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“…( 43 ) In our study, iCAFs were mainly observed in PC tissues. CXCL12/CXCR4 might play a role in parathyroid tumor angiogenesis and PTH synthesis modulation ( 25 ) ; therefore, it might be a target for new therapeutic approaches for patients with PHP.…”

Section: Discussionmentioning

confidence: 99%

“…Fibroblasts are known to be heterogeneous; however, their heterogeneity in parathyroid tumors is unclear. (25) We detected five clusters of fibroblasts, musculature cells, including CD55 + fibroblasts, ACTA2 + fibroblasts, smooth muscle cells and myofibroblasts, inflammatory cancer-associated fibroblasts (iCAFs), and pericytes (Fig. 4B and Supplemental Fig.…”

Section: Role Of Stromal Cells In Coordinating the Tme In Parathyroid...mentioning

confidence: 94%

Single‐Cell Transcriptomic Atlas of Parathyroid Adenoma and Parathyroid Carcinoma

Chen

Shan

et al. 2023

J of Bone & Mineral Res

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Primary hyperparathyroidism is typically characterized by monoclonal parathyroid tumors that secrete an excessive amount of parathyroid hormone (PTH). However, the underlying pathogenesis of tumorigenesis remains unclear. We performed single‐cell transcriptomic analysis on five parathyroid adenoma (PA) and two parathyroid carcinoma (PC) samples. A total of 63,909 cells were divided into 11 different cell categories; endocrine cells accounted for the largest proportion of cells in both PA and PC, and patients with PC had larger populations of endocrine cells. Our results revealed significant heterogeneity in PA and PC. We identified cell cycle regulators that may play a critical role in the tumorigenesis of PC. Furthermore, we found that the tumor microenvironment in PC was immunosuppressive, and endothelial cells had the highest interactions with other cell types, such as fibroblast‐musculature cells and endocrine cells. PC development may be stimulated by fibroblast‐endothelial cell interactions. Our study clarifies the transcriptional signatures that underlie parathyroid tumors and offer a potential significant contribution in the study of pathogenesis of PC. © 2023 American Society for Bone and Mineral Research (ASBMR).

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