Paratrimerins G and H, two prenylated phenolic compounds from the stems of Paramignya trimera

Phytochemical Screening and Potential Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Xao Tam Phan (Paramignya trimera (Oliv.) Guillaum) Peels against Multidrug-Resistant Bacteria

“…Terpenoids and steroids, known as nonpolar compounds, dominate logically in nondefatted portion NDP rather than in DP. This phytochemical screening result was consistent with previous studies showing the profiles of roots and stems of P. trimera [ 9 – 19 ].…”

“…To go deeply into the phytochemical composition of these extracts above, we dereplicated known metabolites using LC-HRMS analysis. e exact mass of detected components was compared to those of reference compounds shown in previous studies [9][10][11][12][13][14][15][16][17][18][19] (Table 1S, Supplementary Materials). e QTOF MS-based chromatograms on nondefatted and defatted peels clearly showed similar and different segments between the two samples (Figure 1).…”

“…Recently, various potential bioactivities, i.e., antioxidant, antibacterial, and anticancer activities and hepatoprotective property, were reported from the plant's roots, leaves, and stems. Many compounds that belong to coumarins, acridone alkaloids, phenols, flavonoids, and chromenes classes have been isolated from these tissues (Table 1S, Supplementary Materials) [9][10][11][12][13][14][15][16][17][18][19]. Furthermore, being a perennial woody plant, the exploitation of this plant from other tissues, i.e., fruits, instead of roots, leaves, or stems, may provide a chance to conserve this valuable medicinal plant.…”

New Constituents From the Roots and Stems of Paramignya trimera

“…6,12 Recent pharmacological studies have shown that P. trimera possesses antioxidant, [12][13][14] cytotoxic, 12 hepatoprotective, 12 anti-inflammatory, 8 antiproliferative, 14 and α-glucosidase inhibitory activities. [9][10][11] In our previous paper, a series of coumarins, including ninhvanin, ostruthin, and 6-(6-hydroxy-3,7-dimethylocta-2,7-dienyl)-7-hydroxycoumarin, together with 2 dimeric monoterpene-linked coumarin glycosides, paratrimerin A and B, were reported from the roots and stems of P. trimera. 6,7 In this paper, we report the isolation and characterization of 3 new compounds from the roots and stems of P. trimera: ninhvanin B (1), paramitrimerol (2), and parabacunoic acid (3), together with a known alkaloid, citrusinine-I (4).…”

“…6 -8 Coumarin compounds and their glycosides were found to be the dominant chemical class in this genus, together with triterpenes, chromene derivatives, alkaloids, and phenolic compounds. 3 -11 In Vietnamese traditional medicine, P. trimera is well known as a medicinal plant used to treat liver diseases and cancer. 6,12 Recent pharmacological studies have shown that P. trimera possesses antioxidant, 12 -14 cytotoxic, 12 hepatoprotective, 12 anti-inflammatory, 8 antiproliferative, 14 and α-glucosidase inhibitory activities.…”