2015
DOI: 10.1038/nature14553
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Parent stem cells can serve as niches for their daughter cells

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Cited by 182 publications
(161 citation statements)
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References 35 publications
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“…Our HO results indicate JAG1-expressing hepatoblasts appear to be the primary regulator of bile tubule formation in postnatal liver. This is consistent with recent evidence demonstrating that stem cells can provide feed-forward regulation via the Notch pathway on the downstream development of differentiated cells (60).…”
Section: Discussionsupporting
confidence: 81%
“…Our HO results indicate JAG1-expressing hepatoblasts appear to be the primary regulator of bile tubule formation in postnatal liver. This is consistent with recent evidence demonstrating that stem cells can provide feed-forward regulation via the Notch pathway on the downstream development of differentiated cells (60).…”
Section: Discussionsupporting
confidence: 81%
“…Ciliated cell damage in the small airways engenders a replicative response in secretory cell neighbors and subsequent differentiation to restore ciliated cell numbers (Reynolds et al, 2000a). In contrast, surprisingly, ciliated cell ablation in the large airways does not engender increased secretory or basal cell replication or their differentiation into ciliated cells (Pardo-Saganta et al, 2015b). Whether this differing response to ciliated cell loss is due to differences in the ciliated cells themselves or in secretory cells, or due to the presence or absence of basal cells remains unclear.…”
Section: Ciliated Cellsmentioning
confidence: 86%
“…To this end, it has been shown that parent basal cells send ligands to their own daughter secretory cells to activate Notch signaling in these daughter cells. This signal is in fact required for maintaining secretory cell identity and stability (Pardo-Saganta et al, 2015b). However, whether and how such signals regulate de-differentiation remains to be studied, and it could be that multiple signals are required.…”
Section: Factors That Influence Cell Plasticitymentioning
confidence: 99%
“…In the adult, ciliated cells can differentiate from both basal progenitors and secretory cells in mouse airways (Rawlins et al 2009;Lafkas et al 2015;Pardo-Saganta et al 2015b;Watson et al 2015). Electron microscopy (EM) suggests the same events of (trans-)differentiation from secretory-to-ciliated cells in human and quail oviducts under hormonal control Hagiwara 1995).…”
Section: Multiciliated Epithelia Across Animalsmentioning
confidence: 99%