Paris polyphylla extract inhibits proliferation and promotes apoptosis in A549 lung cancer cells

Hu, Ruofei; Yu, Wei; Zhuo, Yan; Yang, Yi-Hong; Hu, Xiaogang

doi:10.4314/tjpr.v16i9.11

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Te anticancer, antioxidative, expectorant, platelet aggregation inhibition, insecticidal, antidiabetic, antifungal/ antiyeast, antiparasitic, antibacterial, antihyperlipidemic, and anti-infammatory properties of steroid saponins are just a few of their medical applications. Te biological activity of steroidal saponins and additional ingredients was investigated against cancer cell lines, bacteria, enzymes, and other parasites that have demonstrated anticancer activity against oesophageal cancer [52], lung cancer, bone cancer, prostate cancer, breast cancer, bladder cancer, liver cancer, and colon cancer [53]. In addition, P. polyphylla rhizome extract and steroidal saponins shown antibacterial and antioxidant action [54].…”

Section: Pharmacologymentioning

confidence: 99%

Traditional Uses, Active Ingredients, and Biological Activities of Paris polyphylla Smith: A Comprehensive Review of an Important Himalayan Medicinal Plant

Rawat

Pandey

Rawat

et al. 2023

Journal of Chemistry

View full text Add to dashboard Cite

Paris polyphylla Smith (family: Melanthiaceae), a high-value medicinal herb endemic to the Himalayan region, has drawn much attention recently due to its immense use in the traditional healthcare system since ancient times. In the present review, an extensive database on P. polyphylla was systematically searched from databases such as Medline/PubMed, Scopus, the Web of Science, and the online service E-library.ru and SCImago (https://www.scimagojr.com/). Information on species, ecology, distribution, trade, ethnopharmacology, pharmacology, biotechnology, and molecular biology was gathered from 1979 to 2023 using 116 research publications. Major steroidal saponins such as Paris saponin I, V, VI, VII, and H have been found substantially effective in anticancer activity, abnormal uterine bleeding, dysfunctional uterine bleeding, and menorrhagia. Traditional breeding and propagation techniques cannot keep up with the world’s growing demand for herbal drugs. Therefore, it is critically necessary to take conservation measures and develop novel techniques for growing and cultivating this economically significant and highly valuable therapeutic herb. The advanced biotechnological approaches like micropropagation and genetic analysis introduced long back are either rare or lacking in the case of P. polyphylla. It contains a wealth of information that will serve as a baseline data source for various stakeholders, researchers working on various research aspects, and policymakers to define appropriate utilization and conservation plans for a high-value commercial medicinal plant called P. polyphylla. The review provides an updated overview and critical assessment of secondary data regarding the past and recent applications and interventions of P. polyphylla.

show abstract

Section: Pharmacologymentioning

confidence: 99%

Traditional Uses, Active Ingredients, and Biological Activities of Paris polyphylla Smith: A Comprehensive Review of an Important Himalayan Medicinal Plant

Rawat

Pandey

Rawat

et al. 2023

Journal of Chemistry

View full text Add to dashboard Cite

show abstract

“…Many clinically utilized cancer chemotherapy drugs are derived from natural products, which are still hotspots for innovative lead discovery (Newman and Cragg, 2012). Methanol, ethanol, petroleum ether, water and dichloromethane extracts as well as steroidal saponins obtained from various parts of P. polyphylla such as the rhizome, root, leaves, stem and whole plant have shown anticancer activity against lung cancer (Yan et al, 2009;Li et al, 2013;He et al, 2014;Hu et al, 2017;Qin et al, 2018), oesophagal cancer , bone cancer (Ruamrungsri et al, 2016), prostate cancer (Zhang et al, 2018), breast cancer (Qin et al, 2018), bladder cancer (Guo et al, 2018), liver cancer (Qin et al, 2018), colon cancer (Qin et al, 2018) and digestive cell cancer (Sun et al, 2007). Methanol extract had the lowest IC 50 of <10 μg/mL in both chondrosarcoma cell lines and normal canine primary chondrocyte cells (Ruamrungsri et al, 2016).…”

Section: Lin Et Al (2015)mentioning

confidence: 99%

Bioactive secondary metabolites in Paris polyphylla Sm. and their biological activities: A review

Thapa

Paudel

Bhattarai

et al. 2022

Heliyon

View full text Add to dashboard Cite

Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves

Zhou

et al. 2022

Molecules

View full text Add to dashboard Cite

Paris polyphylla var. chinensis (Franch.) Hara is a perennial herb belonging to the Trilliaceae family. Ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q–TOF MS) was used to detect the composition of different fractions of Paris polyphylla var. chinensis leaves. Meanwhile, the extracts of different fractions were evaluated for their cytotoxic activities against four selected human cancer cell lines and one human normal epithelial cell line based on the MTT assay method. Multivariate statistical analysis was performed to screen differential compounds and to analyze the distributions between different fractions. Finally, more than 60 compounds were obtained and identified from the different fractions of Paris polyphylla var. chinensis leaves, and the chloroform and n−butanol extracts showed significant cytotoxic effects on these four cancer cells. Several compounds were preliminarily identified from different fractions, including 36 steroidal saponins, 11 flavonoids, 10 ceramides, 8 lipids, 6 organic acids, and 8 other compounds. Various compounds were screened out as different chemical components of different fractions, which were considered as a potential substance basis for the cytotoxicity of Paris polyphylla var. chinensis leaves.

show abstract

Paris polyphylla extract inhibits proliferation and promotes apoptosis in A549 lung cancer cells

Abstract: Purpose: To investigate the effect of Paris polyphylla extract (PPE) on proliferation and apoptosis in p21ras protein (p < 0.01

Cited by 3 publications

References 14 publications

Traditional Uses, Active Ingredients, and Biological Activities of Paris polyphylla Smith: A Comprehensive Review of an Important Himalayan Medicinal Plant

Traditional Uses, Active Ingredients, and Biological Activities of Paris polyphylla Smith: A Comprehensive Review of an Important Himalayan Medicinal Plant

Bioactive secondary metabolites in Paris polyphylla Sm. and their biological activities: A review

Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves

Contact Info

Product

Resources

About