Parkinson’s disease progression: Increasing expression of an invariant common core subnetwork

Spetsieris, Phoebe G.; Eidelberg, David

doi:10.1016/j.nicl.2023.103488

Cited by 2 publications

(2 citation statements)

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“…S4). In contrast to the stepwise increases in PDRP expression seen with increasing disease duration, STN StimNet values began to approach a oor four years from the time of diagnosis [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

“…4C). To this end, we analyzed FDG PET scans from 175 Site 1 PD patients, who were divided into roughly 4-year blocks based on the time from clinical diagnosis [25,26,71]. For each patient, we computed whole-brain STN StimNet expression and standardized the measurements with respect to corresponding values from 33 healthy control subjects [72].…”

Section: Predictive Modelsmentioning

confidence: 99%

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Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: A network imaging marker of the treatment response

Unadkat,

Vo,

et al. 2024

Preprint

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Subthalamic nucleus deep brain stimulation (STN-DBS) alleviates motor symptoms of Parkinson’s disease (PD), thereby improving quality of life. However, quantitative brain markers to evaluate DBS responses and select suitable patients for surgery are lacking. Here, we used metabolic brain imaging to identify a reproducible STN-DBS network for which individual expression levels increased with stimulation in proportion to motor benefit. Of note, measurements of network expression from metabolic and BOLD imaging obtained preoperatively predicted motor outcomes determined after DBS surgery. Based on these findings, we computed network expression in 175 PD patients, with time from diagnosis ranging from 0 to 21 years, and used the resulting data to predict the outcome of a potential STN-DBS procedure. While minimal benefit was predicted for patients with early disease, the proportion of potential responders increased after 4 years. Clinically meaningful improvement with stimulation was predicted in 18.9 – 27.3% of patients depending on disease duration.

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Section: Discussionmentioning

confidence: 99%