Parotid gland involvement as a presenting feature of Wegener’s granulomatosis

Sialadenitis is an inflammation or infection of the salivary glands that may affect the parotid, submandibular and small salivary glands. Imaging findings vary among unilateral or bilateral salivary gland enlargement, atrophy, abscess, ductal dilation, cysts, stones and calcification. Imaging can detect abscess in acute bacterial suppurative sialadenitis, ductal changes with cysts in chronic adult and juvenile recurrent parotitis. Imaging is sensitive for detection of salivary stones and stricture in obstructive sialadenitis. Immunoglobulin G4-sialadenitis appears as bilateral submandibular gland enlargement. Imaging is helpful in staging and surveillance of patients with Sjögren's syndrome. Correlation of imaging findings with clinical presentation can aid diagnosis of granulomatous sialadenitis. Post-treatment sialadenitis can occur after radiotherapy, radioactive iodine or surgery.

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“…Salivary gland involvement typically occurs early in the course of the disease and may be seen in limited forms of the disease. 20–31…”

Section: Granulomatous Sialadenitismentioning

confidence: 99%

Imaging of sialadenitis

Razek

Mukherji

2017

Neuroradiol J

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“…Aunque el compromiso de glándulas salivales es anecdótico, existen algunos casos reportados donde se han presentado como los únicos y primeros signos de la enfermedad, se evidencian glándulas incrementadas de tamaño con o sin áreas necróticas con trayectos fistulosos a piel. Las principalmente afectadas son las glándulas salivales mayores (submandibulares o parótidas) (27).…”

Section: Compromiso De Glándulas Salivalesunclassified

Enfoque otorrinolaringológico de la granulomatosis con poliangeítis (de Wegener) Otolaryngologic approach to granulomatosis with polyangitis (Wegener’s)

Ariza

Rojas

2018

Acta otorrinolaringol cir cabeza cuello

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Introducción: La granulomatosis con poliangeítis (de Wegener) es una enfermedad poco frecuente, sin embargo, el 80 a 90% de los casos tienen manifestaciones otorrinolaringológicas, muchas como único síntoma inicial de la enfermedad. Objetivos: El propósito de este artículo es revisar la literatura disponible actualizada sobre granulomatosis con poliangeítis: manifestaciones clínicas, estándares de enfoque, diagnóstico y tratamiento en otorrinolaringología. Diseño: Revisión narrativa de la literatura. Materiales y métodos: Revisión de la literatura mediante búsqueda selectiva por términos MeSH: Otorhinolaryngologic Diseases, Granulomatosis with polyangiitis, Wegener Granulomatosis, de las bases de datos:MEDLINE, Current Contents, Cochrane, Pubmed y Scielo, entre los años 2000 y 2014. Resultados: Se revisaron 39 artículos según los requerimientos de los objetivos. La evidencia científica actual reconoce la importancia del conocimiento sobre granulomatosis con poliangeítis (de Wegener) en otorrinolaringología, para obtener diagnósticos tempranos y ofrecer manejos oportunos. Conclusiones: El diagnóstico y tratamiento tempranos de la granulomatosis con poliangeítis (de Wegener) son las únicas herramientas para mejorar el pronóstico y calidad de vida de los pacientes con esta enfermedad.Introduction: Granulomatosis with polyangiitis (Wegener’s) is a rare disease,however 80% to 90% of the cases have otolaryngologic manifestations, many as initial symptoms of the disease. Objectives: The purpose of this article is to review the current literature about granulomatosis with polyangiitis: Clinic manifestations, approach standards, diagnosis and treatment in otolaryngology. Design: Narrative review. Materials and methods: Literature review by selective search for MeSH terms: Otorhinolaryngologic Diseases, granulomatosis with polyangiitis, Wegenergranulomatosis, in the databases: MEDLINE, Current Contents, Cochrane, PubMed and SciELO, between 2000 and 2014. Results: 39 articles were reviewed according to the requirements of the objectives. Current scientific evidence recognizes the importance of the knowledge about granulomatosis with polyangiitis (Wegener’s) in otolaryngology, in order to give an early diagnosis and to provide an opportune treatment. Conclusions: Early diagnosis and treatment of granulomatosis with polyangiitis (Wegener’s) are the only tools to change the prognosis as well as quality of life of patients with this disease.

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“…A rare manifestation of the GPA is parotitis, submucosal or sublingual salivary glands inflammation 17 , 18 with its painful enlargement 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

Oral manifestations of granulomatosis with polyangiitis - Clinical and radiological assessment

Szczeklik

Włudarczyk

Wawrzycka-Adamczyk

et al. 2019

Journal of Dental Sciences

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Background/purpose Granulomatosis with polyangiitis (GPA) is a type of primary systemic vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). GPA mainly affects medium and small vessels and may manifest in different organs, most commonly upper respiratory tract. Oral lesions occur in 6–13% of GPA patients and might be the first symptom observed by the patient. This study presents the evaluation of orofacial manifestations of patients with GPA. Materials and methods Prospective study was conducted between June 2014 and November 2017 in Department of Allergy and Immunology at University Hospital in Krakow. Patients diagnosed with GPA, after medical assessment, were examined including precise dental inspection, bacterial and fungal flora of oral cavity evaluation and Cone Beam Computed Tomography (CBCT) imaging. Results Nine patients were enrolled in the study. Characteristic for GPA strawberry gingivitis was observed in one patient. Bone destruction and inflammatory lesions in paranasal sinuses was confirmed by CBCT in 55.6% of patients. Fungal infection was revealed in 66.7% of patients. Conclusion These findings oblige dentists to consult patient with laryngologist or internal medicine physician to establish further diagnostic approach, because early diagnosis of GPA is crucial for implementing appropriate treatment and preventing chronic organ damage.

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Parotid gland involvement as a presenting feature of Wegener’s granulomatosis

Cited by 13 publications

References 13 publications

Imaging of sialadenitis

Imaging of sialadenitis

Enfoque otorrinolaringológico de la granulomatosis con poliangeítis (de Wegener) Otolaryngologic approach to granulomatosis with polyangitis (Wegener’s)

Oral manifestations of granulomatosis with polyangiitis - Clinical and radiological assessment

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