Pars plana vitrectomy as anti-inflammatory therapy for intermediate uveitis in children

25-gauge Vitrectomy for Complicated Chronic Endogenous/Autoimmune Uveitis: Predictors of Outcomes

“…All of them were anecdotal and subjective, however, and had the common shortcomings of a small number of cases, mixture of different disease entities, and short-term follow-up. 2,3,[9][10][11][12][13][14]16,26,27 In our study, VA improvement was gained by 60% of the patients. In another study by our group using sutureless combined 25-gauge vitrectomy, phacoemulsification, and posterior chamber intraocular lens implantation for management of selected patients with uveitic cataract associated with posterior segment disease, final VA was 20/100 in 12 eyes (63.2%) after a minimum of 12 months of follow-up.…”

“…E-mail: masoud_soheilian@yahoo.com armamentarium of the ophthalmologist caring for patients with chronic endogenous uveitis. 2,3,[9][10][11][16][17][18][19] However, there are still some unresolved issues about the effect and outcome of vitrectomy in such cases. For instance, the effect of vitrectomy on resolution of CME, epiretinal membrane formation, and the inflammatory course of uveitis is not well known.…”

Early Experience with Diode Laser Combined with Systemic Steroid Therapy for Severe Stages of Retinopathy of Prematurity

“…It might not be precluded that post-steroids complications could be associated with sulfite preservatives contained in the drug [36]. Relating to the data from available literature, it is worth mentioning that there are no clinical observations in connection to steroids application due to retinopathy of prematurity, although their use is commonly known in different retinal or retino-vitreous diseases even in early childhood, so it appears to be impossible to rely on an opinion of other authors in this field [37][38][39][40][41][42][43][44]. Three-year follow-up of combined laser-steroid course indicate beneficial effect of such therapy in the form of retina attachment which has been confirmed in 88.8 % selected cases.…”

“…Some authors present a lot of evidence that Dexamethasone provides a protective action mechanism against the development of severe retinopathy and extraretinal neovascularization [8,11,14,30,41]. There exists a similarity to inhibitory effects of dexamethasone on TNF-α expression in the retina, as in endotoxin-induced uveitis with the use of local delivery steroid system in experimental model [11][12][13][14], what has been applied in many ophthalmic diseases in children and adults [38,[40][41][42][43]. In the mentioned processes rapid nongenomic effects on cell metabolism and cell membrane functions such as altering intracellular signal transduction pathways, limiting tissular inflammatory reactions by inhibiting migration and aggregation of macrophages with enzyme release and growth factors, fibroblastic activity suppression, reducing vascular permeability and also regulating endothelial nitric oxide synthase by non-nuclear effects are used [9,11-13, 29,36].…”

Intermediate Uveitis

“…For series published after 2005, the median time on medical treatment until vitrectomy was 36 months [209]. Long-term followup of a small series of pediatric patients with intermediate uveitis indicated beneficial results from pars plana vitrectomy (PPV) [216] similar to other series involving children [215,217,218].…”