Part II. The Prognostic Significance of Stromal Eosinophilia in Head and Neck Cancer

Abstract

The pathologies of 82 head and neck tumors were examined for histologic features suggestive of poor prognoses. Twelve descriptive histopathologic variables, including two grading scales for malignant tumors, were correlated with DNA flow cytometric data and clinical outcome. We found no correlation between the grading scales and DNA flow cytometric data or clinical outcome. Only one of the histopathologic variables--stromal eosinophilia--was found to significantly correlate with favorable outcome (p = .018). Stromal eosinophilia may be an important new prognostic indicator for head and neck cancer.

Tumour-Associated Tissue Eosinophilia in Head and Neck Squamous-Cell Carcinoma

“…The prognostic value of TATE is not put to evidence in his paper. In 1987 [21] and 1992 [22] at last. Goldsmith et al reported on 149 squamous-cell carcinomas of the head and neck and concluded that high-grade TATE correlated highly significantly with a favourable clinical outcome.…”

“…We arbitrarily considered TATE as the presence of more than 2 eosinophils/HPF. Goldsmith et al [21,22] consid ered 5 categories of eosinophilic prominence and found the presence of 5-10 eosinophils/HPF as TATE. Lowe and Fletcher [11] and Looi [19] considered more than 10 eosinophils/HPF as moderate TATE and more than 100 eosinophils/HPF as massive TATE.…”

“…Tumours of the skin [3,4], breast [5], cervix [5][6][7][8][9][10]. external genitalia [11], urinary bladder [ 12,13], gastro-intestinal tract [14][15][16][17][18], oral cavi ty [11], nasopharynx [19] and larynx/pharynx [20][21][22] were studied. Conclusions of these reports are not uni form but tend towards a good prognosis in case of a high grade of TATE.…”

Associação do polimorfismo do gene da proteína catiônica eosinofílica com a eosinofilia tecidual associada aos tumores em carcinomas espinocelulares de boca

“…A participação dos eosinófilos nos processos de deposição e remodelação do tecido conjuntivo em diversas condições fisiológicas e patológicas fundamenta a teoria da possível função "reparadora" dessa célula (MUNITZ e LEVI-SCHAFFER, 2004 Especificamente para os pacientes com CEC de boca, alguns estudos (DORTA et al, 2002;GOLDSMITH et al, 1992;GOLDSMITH et al, 1987) têm demonstrado uma correlação da TATE com prognóstico favorável, enquanto outros (WONG et al, 1999;HORIUCHI et al, 1993) a relacionam com um prognóstico desfavorável.…”

“…Contudo, muitos trabalhos (HORIUCHI et al, 1993;GOLDSMITH et al, 1992;GOLDSMITH et al, 1987) (ROSENBERG, 2008;NAVARRO et al, 2008;DYER e ROSENBERG, 2006;CARRERAS et al, 2005;BYSTROM et al, 2002;ZHANG e ROSENBERG, 2000;VENGE et al, 1999;DOMACHOWSKE et al, 1998;VENGE e BYSTROM, 1998; ROSENBERG e DYER, 1995).…”