Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model

Takai, Eri; Taniguchi, Fuminori; Nakamura, Kazuomi; Uegaki, Takashi; Iwabe, Tomio; Harada, Tasuku

doi:10.1016/j.fertnstert.2013.06.028

Cited by 44 publications

(36 citation statements)

References 28 publications

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“…Interestingly, SR seemed to have a more repressive effect than BZA in the growth of murine endometriosis-like lesions. We have also shown the antiproliferative, anti-inflammatory, and anti-angiogenic [31][32][33] Beyond the estrogen-dependent nature of endometriosis, the distinct ER expression profile in endometriosis has also been demonstrated. 2,3,34 In humans, so far, a higher ERβ, and a lower ERα expression in endometriotic tissues, which is in the inverse relationship in the endometrium, has been reported.…”

Section: Discussionmentioning

confidence: 65%

New insights into the efficacy of SR‐16234, a selective estrogen receptor modulator, on the growth of murine endometriosis‐like lesions

Khine

Taniguchi

Nagira

et al. 2018

American J Rep Immunol

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Section: Discussionmentioning

confidence: 65%

New insights into the efficacy of SR‐16234, a selective estrogen receptor modulator, on the growth of murine endometriosis‐like lesions

Khine

Taniguchi

Nagira

et al. 2018

American J Rep Immunol

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“…Previous studies investigated the effect of isoflavones on endometriosis. Puerarin and parthenolide, two flavonoids, inhibited the proliferation of oral epithelial stem cells . Other investigators showed that genistein caused regression of an endometriotic implant using a rat model .…”

Section: Aromatase‐targeting Treatment In Endometriosismentioning

confidence: 99%

“…Puerarin and parthenolide, two flavonoids, inhibited the proliferation of oral epithelial stem cells. 61,62 Other investigators showed that genistein caused regression of an endometriotic implant using a rat model. 63 Our group recently demonstrated that daidzein-rich isoflavone aglycones (DRIA) suppressed cell proliferation in oral epithelial but not in neuroepithelial stem cells at clinically feasible concentrations.…”

Section: Aromatase-targeting Treatment In Endometriosismentioning

confidence: 99%

Aromatase as a target for treating endometriosis

Mori

Ito

Koshiba

et al. 2018

J of Obstet and Gynaecol

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Endometriosis is a common gynecological disease that causes various clinical symptoms, such as chronic pelvic pain, dysmenorrhea and infertility, seriously affecting women's health and their quality of life. The symptoms and endometriotic lesions are relieved, in many cases, after menopause, when estrogen levels are lowered. Therefore, endometriosis is considered to be estrogen-dependent. Aromatase, the enzyme responsible for the last step of estrogen biosynthesis converting testosterone and androgen to estrogen, was previously reported to be more abundant in endometriotic tissues than in the normal endometrium, leading to an increased local estrogen concentration. Therefore, aromatase is considered a key therapeutic target for regulating local estrogen biosynthesis in endometriosis. A more complete understanding of the mechanisms that modulate aromatase and its activity is required to develop novel estrogen-targeted therapies for endometriosis. In this review article, we outline the current understanding of the pathological processes involved in estrogen production in endometriosis and propose novel strategies to treat this disorder.

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“…In mice with induced endometriosis, treatment with parthenolide, derived from the medical herb feverfew, has been shown to reduce number, surface area and weight of endometriosis implants, associated with a reduction in the level of Vegf, Il-6, Mcp-1, and Lif gene expression, and in the percentage of Ki67-positive cells inside these implants [74].…”

Section: Kinase Inhibitorsmentioning

confidence: 99%