Partial Characterization of a Renotropic Factor

Gaydos, D.S.; Goldin, Herzl; Jenson, Bennett; Gersten, Douglas M.; Boedeker, B.; Bartz, C.; Hg, Preuss

doi:10.1159/000172892

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Retropin has only been partially characterized [18], and the site or sites of this production are uncertain [1 -3]. There has been some speculation concerning a role for renotropin in renal sodium homeostasis [11].…”

Section: Discussionmentioning

confidence: 99%

Effects of Sera from Uninephrectomized Rats on Renal Slices: PAH and TEA Uptake and QO<sub>2</sub>

Areas¹,

Slemmer²,

Balian³

et al. 1987

Nephron

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We followed the effects of sera from unilaterally nephrectomized (uninephectomized) rats compared to sham-operated rats on ³Η-p-aminohippurate (³H-PAH) and ¹⁴C-tetraethylammonium (¹⁴C-TEA) uptake and oxygen comsumption (QO₂) in incubating rat kidney slices. These studies were based on the assumption that a circulating renotropic substance might also influence various transport mechanisms. Sera were obtained at various times postoperation; the height of renotropic activity occurs 17–24 h after kidney extirpation. Sera removed 17–24 h postuninephrectomy significantly decreased both ³H-PAH and ¹⁴C-TEA uptake in incubating kidney slices. Similar to the inability to show significant renotropic activity after 36 h, sera obtained 48,96, and 168 h postuninephrectomy had no significant influence on ³H-PAH and ¹⁴C-TEA uptake. Addition of sera (10% v/v) generally depressed QO₂. However, sera obtained from uninephrectomized rats compared to sera from sham-operated rats had relatively more depressive effects on QO₂ in renal tissue after 30 min of incubation (p < 0.01). No significant differences in QO₂ were seen when the uninephrectomized and sham-operated sera were added to the tissue immediately or after 60 min of incubation in the sera. These serum studies on ³H-PAH and ¹⁴C-TEA uptake simulate in many respects ones performed previously with serum from spontaneously hypertensive and salt-loaded rats and suggest the presence of a common circulating factor.

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Section: Discussionmentioning

confidence: 99%

Effects of Sera from Uninephrectomized Rats on Renal Slices: PAH and TEA Uptake and QO<sub>2</sub>

Areas¹,

Slemmer²,

Balian³

et al. 1987

Nephron

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show abstract

“…The maximum is somewhat later and the duration longer in rabbits and man [521]. Heat lability and a molecular size between 12 and 25 kilodaltons are consistent with a small protein as an essential component of the activity [178,255,300,301,369,402], Mitosis is stimulated in medullary as well as cortex slices [369] but liver slices are unaffected [300,305,400,403,404,488]. The stimulatory effect on cortex is interspecific between the rat, dog and mouse [369].…”

Section: Renotropinsmentioning

confidence: 99%

Compensatory Growth and Other Growth Responses of the Kidney

Wesson

1989

Nephron

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“…In summary, the vasoconstrictive factor following uninephrectomy stimulates the characteristics and the time frame of the renal growth factor in rats. 38,39 Renotropin and Sodium Metabolism Abnormal sodium metabolism plays a critical role in hypertension. Enhanced sodium ingestion raises blood pressure, [65][66][67][68][69][70][71] and abnormalities in red and white cell electrolyte concentrations are noted in the hypertensive state.…”

Section: Role Of Renotropin In Hypertensionmentioning

confidence: 99%

Does Renotropin Have a Role in the Pathogenesis of Hypertension?

Preuss

1989

American Journal of Hypertension

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The existence of an organ-specific, circulating renal growth factor, renotropin, has been established through various bioassays. However, renotropin may be more than a growth factor. The pathogenesis of essential hypertension is unknown, although a humoral agent related to renal metabolism is believed to be responsible, at least in part. In parallel with the development of a renotropin assay, we have measured vasomotor and natriuretic serum activities. Our data suggest that renotropin possesses vasomotor and natriuretic properties. Through one or both properties, renotropin may play an important role in essential hypertension. This possibility is strengthened by observations that: a) many methods to produce experimental hypertension involve elevations of renotropin--a reduction of renal mass and/or prevention of compensatory growth; b) high renotropin activity has been demonstrated in genetically hypertensive rats (SHR); and c) sera containing high renotropic activity stimulate contraction of isolated rat aortic rings and influence organic anion and cation transport.

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Partial Characterization of a Renotropic Factor

Cited by 3 publications

References 4 publications

Effects of Sera from Uninephrectomized Rats on Renal Slices: PAH and TEA Uptake and QO<sub>2</sub>

Effects of Sera from Uninephrectomized Rats on Renal Slices: PAH and TEA Uptake and QO<sub>2</sub>

Compensatory Growth and Other Growth Responses of the Kidney

Does Renotropin Have a Role in the Pathogenesis of Hypertension?

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