Partial characterization of red gram (Cajanus cajan L. Millsp) polypeptides recognized by patients exhibiting rhinitis and bronchial asthma

Cutaneous exposure to clinically-relevant pigeon pea (Cajanus cajan) proteins promote TH2-dependent sensitization and IgE-mediated anaphylaxis in Balb/c mice

“…Environmental exposure to allergens in the context of an impaired skin barrier (as seen in AD) due to mutations in the filaggrin gene are thought to promote a cutaneous sensitization that could lead to development of food anaphylaxis (FA) (Sicherer and Leung 2015). Interestingly, in a previous study, some pigeon pea-allergic patients were found to have AD-like symptoms such as urticaria (Misra et al 2010). This suggested that, besides oral, an epicutaneous (EC) route could be a route for sensitization that could ultimately give rise to food-related anaphylaxis.…”

“…Further, out of 113 asthmatic patients, 8.8% patients were found to have positive reactions with pigeon pea allergen (Misra et al 2010). Pigeon pea contains five allergens, that is, Caj c1, Caj c2, Caj c3, Caj c4, Caj c5, that can induce allergic reaction in patient(s) suffering from nasobronchial asthma, allergic rhinitis and skin diseases (Misra et al 2010). The existence of potential cross-reactivity between pigeon pea allergens with other allergens from soy bean, green gram and chick peas has been previously reported (Misra et al 2010).…”

“…Several reports have reflected the role of legumes, including peanuts, chickpeas, red kidney beans, green gram and broad beans in provoking anaphylactic symptoms in Balb/c mice (Misra et al 2010;Verma et al 2012;Kumar et al 2013). Food-dependent exerciseinduced anaphylaxis to chickpea and soya bean allergens have been reported in sensitized individuals (Orhan & Karakas 2008;Adachi et al 2009;Ciccarelli et al 2014).…”

“…Pigeon pea is consumed in a form that contains % 22% protein along with most essential amino acids (Misra et al 2010). Over the past decade, pigeon pea allergy has become very prevalent in the Indian subcontinent due to high consumption of the product.…”

“…Misra et al (2008) reported that out of total legume-allergic patients, 21% of the patients had pigeon pea allergy. Further, out of 113 asthmatic patients, 8.8% patients were found to have positive reactions with pigeon pea allergen (Misra et al 2010). Pigeon pea contains five allergens, that is, Caj c1, Caj c2, Caj c3, Caj c4, Caj c5, that can induce allergic reaction in patient(s) suffering from nasobronchial asthma, allergic rhinitis and skin diseases (Misra et al 2010).…”