2023
DOI: 10.48550/arxiv.2302.09445
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Partial differential equation-based inference of migration and proliferation mechanisms in cancer cell populations

Abstract: Targeting signaling pathways that drive cancer cell migration or proliferation is a common therapeutic approach. A popular experimental technique, the scratch assay, measures the migration and proliferation-driven cell monolayer formation. Scratch assay analyses do not differentiate between migration and proliferation effects and do not attempt to measure dynamic effects. To improve upon these methods, we combine high-throughput scratch assays, continuous video microscopy, and variational system identification… Show more

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