Partial Hydatidiform Mole with a Live Fetus— A Rare Entity

Abstract

Partial hydatidiform mole (PHM) with a singleton live fetus is a rare condition. A live baby of 2000 grams with many external congenital anomalies like hydrocephalus, bilateral congenital talipus equino varus (CTEV), meningomyelocele and spina bifida was delivered. Placenta weighed 700 grams and PHM was confirmed by histopathological examination. Baby expired one hour after birth. Baby was sent for autopsy which documented various anomalies. Partial hydatidiform mole is a histopathological entity characterized by focal trophoblastic hyperplasia with villous hydrops together with identifiable fetal tissue. PHM with a single live fetus is a rare condition which is reported by very few authors. Not all the cases of partial mole can be detected by USG/Doppler. If any anomalies are detected, PHM should be thought among the conditions possible. MShCG and karyotyping can be done to rule out this condition. Placenta has to be sent for histopathological examination to confirm the diagnosis of PHM. These patients are prone to go in preterm labor and preterm premature rupture of membranes (PPROM). There is possibility of malpresentations like transverse lie among these cases.

Singleton Partial Molar Pregnancy Delivered in Third Trimester: A Case Report

“…Maternal risks include abnormal bleeding, hyper emesis gravidarum, preeclampsia, eclampsia, hyperthyroidism, anemia, preterm labor, mal-presentation like transverse lie, Preterm premature rupture of membrane (PROM), persistent trophoblastic disease and abruption. Fetal complications include abortion, congenital anomalies, preterm, severe anemia due to limited placental circulation, IUGR and intra uterine fetal death (IUFD) [6,[11][12][13][14][15]. In our case, hyper emesis gravidarum, preeclampsia, eclampsia, preterm delivery, mal-presentation (breech) and fetal anemia were seen Table 1.…”

“…In PM there is partial replacement with hydropic villi and visible abnormal fetal parts mostly leading to termination of pregnancy in the first trimester. It presents with several dilemmas in management during pregnancy and the woman must be counseled regarding the maternal and fetal complications and the risk of persistent trophoblastic disease in later life [10][11][12][13].…”

Grossesse molaire partielle avec fœtus diploïde vivant: à propos d'un cas et revue de la littérature

“…Le diagnostic précoce d’une MHP conduit dans la majorité des cas à une interruption de la grossesse d’une part du fait de la fréquence des triploïdies et d’autre part du fait du risque maternel et la possibilité d’évolution vers la maladie trophoblastique persistante ultérieurement [ 11 , 12 ]. Une surveillance étroite de la mère et du fœtus peut aider à atteindre un résultat favorable, et l’évacuation de la grossesse n’est requise que dans les cas des anomalies fœtales ou une détérioration de l'état maternel [ 13 ].…”

Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report

“…In cases of such association other possibilities should be considered [5,9]. The first is a twin pregnancy with one normal fetus (normal placenta) and another complete mole, the second is a twin pregnancy with fetus and normal placenta and partial hydatidiform moles, and the third and less common is a pregnancy with normal singleton fetus with partial molar placenta, where the fetus must have normal karyotype to survive in utero, although its placenta can have some chromosomal variation, from diploidy of the amnion to triploidy of the chorionic villi [5,7,8,11]. The majority of pregnancies in which molar change has been reported in association with a live fetus represent dizygotic twin pregnancies in which one fertilization results in a complete hydatidiform mole and the other a normal co-twin.…”