Partial Immunologic Tolerance to the Human B but not to the A Antigen

Grundbacher, F. J.; Shreffler, D C

doi:10.1159/000230598

Int Arch Allergy Immunol

1972

DOI: 10.1159/000230598

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Partial Immunologic Tolerance to the Human B but not to the A Antigen

F. J. Grundbacher¹,

D C Shreffler²

Abstract: Quantitation of anti-A and anti-B isoantibodies in 472 selected children of the Tecumseh population has provided strong evidence that the A antigen of the mother does not induce any immunologic tolerance in her group-O children. Mean levels of hemolytic and saline anti-B, on the other hand, were lower in children of mothers with the B antigen than in children of mothers who lacked B, thus, indicating that the B antigen of the mother induces partial immunologic tolerance in her children.

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1976

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Genetics of Anti‐A and Anti‐B Levels

Grundbacher¹

1976

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Hemolysins and agglutinins anti‐A and anti‐B were measured in 401 blood group O individuals belonging to 74 families. Levels of hemolysins and saline agglutinins reached a peak during childhood and decreased thereafter. Incomplete agglutinins showed a relative increase after childhood. Hemolysins and agglutinins were higher in blacks than in whites. Whites had higher anti‐A than anti‐B levels and the levels were higher in females than in males. In blacks the anti‐B levels were almost as high as were the levels of anti‐A and little sex difference was found. Levels of hemolytic anti‐A and saline anti‐A were closely correlated as were hemolytic anti‐B and saline anti‐B but low correlations were found between anti‐A and anti‐B levels. Anti‐A and anti‐B hemolysin and agglutinin levels were positively correlated with serum IgM levels. Anti‐B levels were also correlated with IgG levels but anti‐A levels were not. Isoantibody levels were not correlated with IgA, IgD, and IgE levels. Correlation and regression analysis among relatives disclosed that from 20 to 30 per cent of the total phenotypic variation in isoantibody levels was accounted for by genetic variation. Age of the individual also contributed markedly to the variation in hemolysins and saline agglutinins, but about one‐half of the total variation remained unaccounted for.

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Genetics of Anti‐A and Anti‐B Levels

Grundbacher¹

1976

Transfusion

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Partial Immunologic Tolerance to the Human B but not to the A Antigen

Cited by 1 publication

References 3 publications

Genetics of Anti‐A and Anti‐B Levels

Genetics of Anti‐A and Anti‐B Levels

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