Partial luteolysis during early diestrus in cattle downregulates VEGFA expression and reduces large luteal cell and corpus luteum sizes and plasma progesterone concentration

Trevisol, Eduardo; García, Henry David Mogollón; Ackermann, C. L.; Lacerda, W.; Pires, Rita Maria Ladeira; Laufer-Amorin, R.; Carvalho, Robson Francisco; Franchi, F; Castilho, A. C. S.; Rizzoto, Guilherme; Kastelic, John P.; Ferreira, João Carlos Pinheiro

doi:10.1016/j.theriogenology.2020.09.015

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Our current study showed a significant increase of FASLG gene with significance in mid stage of CL compared to early and late stages. In agreement with our study, Planells-Ferrer et al (2016) found that, FAS expression combined with apoptosis and expressed in the early stage of CL in cows (Trevisol et al, 2020).…”

Section: Discussionsupporting

confidence: 91%

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Galal¹,

Ibrahim²,

Mahmoud³

et al. 2022

AAVS

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B uffaloes (Bubalus bubalis) play an important part in many poor countries. They are used for agricultural economies, producing milk, meat, and draught force (Minervino et al., 2020). One of the greatest constraints in the exploitation of the production potential of buffaloes are its inherently lower reproductive efficiency, manifested by es-trus with low behavioral expression and/or not associated with ovulation, postponed sexual maturity, lower conception rates, and longer calving intervals (Baithalua et al., 2013).The corpus luteum (CL), a dynamic endocrine gland, controls the estrous cycle, embryonic development, implantation, and produce progesterone (P4), which is essential for research Article Abstract | It is fair to know how corpus luteum (CL) is a maestro of regulation of estrus cycle in Egyptian buffaloes. Hence, the study of molecular control of the CL in Egyptian buffaloes let us to know the mechanisms of this regulation. We aimed to (1) figure out the expression profile of apoptotic genes (TNF α -BAX -CASP3 -FASLG -AGTR2 -and NOS2) mRNAs during early, mid, and late stages of CL and (2) clarify the accompanied changes in progesterone (P4), nitric oxide (NO) concentrations and histological evaluation through different stages of CL in buffaloes. Forty five paired samples of ovarian tissue from buffaloes were obtained from slaughterhouse. Ovaries were collected and CLs were classified morphologically into three stages: early, mid and late stages. Moreover, the CLs were frozen at -80 °C for NO estimation in CLs homogenate, RNA isolation and gene expression. Blood samples were obtained for P4 serum levels estimation. Results showed a significant rise of TNF α mRNA during late stage of CL and increase the expression of CASP3, FASLG and AGTR2 mRNAs during mid-stage of CL. Furthermore, NOS2 mRNA was raised during early stage of CL. Surprisingly, NO in CL homogenate was raised through early and late stages of CL. Additionally, P4 increased in mid-stage of CL. Taken together, the fine tuning between apoptotic genes (TNF α -BAX -CASP3 -FASLG -AGTR2 -and NOS2) is required for proper functions of CL in Egyptian buffaloes. Thus, it might be concluded that expression pattern of apoptotic genes is changed according to the stage of CL.

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Section: Discussionsupporting

confidence: 91%

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Galal¹,

Ibrahim²,

Mahmoud³

et al. 2022

AAVS

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“…Investigaciones previas han demostrado que en condiciones normales las vacas preñadas permanecen en el rebaño 420 días más comparadas con sus compañeras de grupo que están "abiertas" (no preñadas). Bajo condiciones ideales una vaca debería preñarse 85 días después del parto para poder alcanzar una producción de leche óptima (Trevisol et al, 2020). Se recomienda que estas vacas deben parir cada 12,5-13 meses.…”

Section: Introductionunclassified

Efecto en la eficiente reproductiva mediante el uso de dos protocolos (eCG y Ovsynch) para IATF en ganado bovino tropical

Sánchez-Cárdenas

Vargas-Rodríguez

2023

Rev. Vet. Zootec. Amaz.

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La situación económica mundial requiere de prácticas de manejo eficaces para mejorar la rentabilidad de los establecimientos de producción de leche, especialmente, en ganadería de trópico. El objetivo es demostrar el efecto en la eficiencia reproductiva mediante el uso de dos protocolos (eCG y Ovsynch) para IATF en ganado bovino de trópico. La metodología fue mediante tratamientos, con un diseño de bloque completamente al azar; se aplicaron bases de Ovsynch y el análisis de datos fue mediante el software InfoStat para análisis de varianza. Los resultados obtenidos fueron del tratamiento de 40 vacas a las que se aplicó el protocolo modificado (eCG), 26 (65%) resultaron preñadas a la palpación rectal a los 55 días de gestación y de 33 vacas a las que se aplicaron el protocolo tradicional de Ovsynch, 17 (51%) dieron positivo al diagnóstico de gestación transrectal al día 55 de la gestación. En conclusión, la inseminación a tiempo fijo en vacas Bos indicus lactantes y con los protocolos de Ovsynch es factible la detección de celos y preñez.

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Bovine models for human ovarian diseases

Roberts

Huang

2022

Progress in Molecular Biology and Translational Science

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Partial luteolysis during early diestrus in cattle downregulates VEGFA expression and reduces large luteal cell and corpus luteum sizes and plasma progesterone concentration

Cited by 4 publications

References 22 publications

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Expression Pattern of Apoptotic Genes During Different Stages of Corpus Luteum Development in Egyptian Buffaloes

Efecto en la eficiente reproductiva mediante el uso de dos protocolos (eCG y Ovsynch) para IATF en ganado bovino tropical

Bovine models for human ovarian diseases

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